A Multi-center RCT Study on the Efficacy and Mechanism of Multi-channel tDCS in Rehabilitation of Cognitive Function After Stroke

Phase

N/A

Condition

Dementia

Mild Cognitive Impairment

Memory Loss

Treatment

N/A

Clinical Study ID

NCT04133714

2019-313

Ages 18-60
All Genders

Study Summary

This clinical RCT study intends to combined different forms of multi-channel tDCS with the routine cognitive training process to treat patients with post-stroke cognitive dysfunction.

The therapeutic effects among single-channel tDCS group, multi-channel tDCS and pseudo-multichannel tDCS group will be compared. Brain magnetic resonance mechanism research will also be included to reveal the possible mechanism of multi-channel tDCS technology for PSCI brain network.

Thus, the efficacy and mechanism of multi-channel tDCS in post-stroke cognitive function rehabilitation will be researched both in the clinical and basic levels.

Eligibility Criteria

Inclusion

Inclusion Criteria:

18-60 year-old
diagnosed cerebral apoplexy, meeting the diagnostic criteria of ICD-10
cognitive function, perceptual function decline after stroke
first onset and duration of 3-12 months
right-handed
MMSE ≤25
MoCA ≤25
sign informed consent voluntarily and comply with the study plan

Exclusion

Exclusion Criteria:

NIHSS ≥21 points
MoCA ≤18, or DRS-2 ≤ 124, or CES-D ≥ 16
taking drugs that affect central nervous activity, such as nerve antagonists
specific contraindication, such as electrode patch allergy, local skin injury or - - -
inflammation, and hyperalgesia in stimulated areas
patients use implantable electronic devices (such as cardiac pacemakers) or have -metal implants such as stents that affect MRI examination
patients with a previous history of epilepsy, mental illness or skull injury
patients with dementia or obvious cognitive dysfunction before stroke
patients with aphasia or dysarthria and cannot complete the scale evaluation
pregnancy

Study Design

November 01, 2020

December 31, 2023

Connect with a study center

Rainbowfish Rehabilitation Nursing Care
Hangzhou, Zhejiang 310000
China
Active - Recruiting
SAHZhejiangU
Hangzhou, Zhejiang 310009
China
Active - Recruiting
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang 310014
China
Active - Recruiting
Southwest Hospital
Chongqing, 400000
China
Active - Recruiting

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