High Resolution, High-speed Multimodal Ophthalmic Imaging

Last updated: October 11, 2024
Sponsor: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Overall Status: Active - Recruiting

Phase

N/A

Condition

Retinitis Pigmentosa

Inflammation

Stroke

Treatment

High-resolution retinal imaging through holographic systems

High-resolution retinal imaging through adaptive optics

Clinical Study ID

NCT04129021
P19-03
2019-A00942-55
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye.

The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in the retina, cells and nerves in the cornea.

The use of a high-speed acquisition imaging system makes it possible to detect functional measurements such as the speed of blood flow. The combination of data from multiple imaging systems to obtain multimodal information is of great importance for improving the understanding of structural changes in the eye during a disease.

The purpose of this project is to observe structures that are not detectable with routinely used systems.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • People over 18

  • Patient with a pathology affecting the eye or healthy volunteer

  • Participant who signed the consent

  • Beneficiaries of the health insurance

Exclusion

Exclusion Criteria:

  • Patients with a history of photosensitivity.

  • Patients who have just received a photodynamic therapy treatment (

  • Patients taking drugs with photosensitivity as a side effect.

  • Persons with pacemakers or other implanted electronic medical device

  • Patients with viral conjunctivitis or any other infectious disease.

  • Patients with skin lesions on the neck or forehead

  • Patients at high risk of damage from optical radiation, such as aphakic patients, orpatients with decreased sensitivity to light due to fundus disease.

  • Pregnant or lactating women

  • Participant unable to be followed throughout the study

  • Vulnerable people

  • Subjects with predisposition to closure of the iridocorneal angle

Study Design

Total Participants: 1200
Treatment Group(s): 2
Primary Treatment: High-resolution retinal imaging through holographic systems
Phase:
Study Start date:
July 03, 2019
Estimated Completion Date:
July 31, 2027

Study Description

The goal of the project is the capture and analysis of images with the IMA-MODE systems, in order to evaluate the performance of these systems compared to the existing clinical imaging devices used at the National Hospital of Ophthalmology.

This project should identify the best techniques to image the eye, and select the most promising techniques to evolve towards a possible development of a medical device.

Connect with a study center

  • Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts

    Paris, 75012
    France

    Active - Recruiting

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