Post-contracture Release Radiation for Dupuytren's Disease

Last updated: February 25, 2025
Sponsor: University of Minnesota
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dupuytren's Disease

Treatment

Evaluation of Dupuytren's Disease Treatment

Clinical Study ID

NCT04122313
ORTHOSURG-2018-26681
  • Ages > 18
  • All Genders

Study Summary

To determine if the clinical impression of clinicians, ie that patients are improving with the current treatment pathway for Dupuytren's (contracture release followed by radiation), can be substantiated with scientific evidence.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnoses of Dupuytren's disease

  • English-speaking

Exclusion

Exclusion Criteria:

  • Patients with Dupuytren's disease who are not currently seeking treatment

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Evaluation of Dupuytren's Disease Treatment
Phase:
Study Start date:
May 31, 2019
Estimated Completion Date:
March 01, 2026

Study Description

This is an observational, pilot study. Participants will be treated according to a standard treatment pathway, which includes contracture release treatment modalities such as limited fasciectomy, PNA and CCH injection, followed by post-operative radiation. All enrolled participants will undergo radiation treatment as soon as possible following contracture release. Radiotherapy will consist of 5 daily treatments of 300 cGy delivered to the palmar area followed by a 6-8 weeks break then a second 5 day course of radiation at 300 cGy, for a total of 3000 cGy in 10 total fractions. This dosing schedule is commonly used in the published literature. The data to be collected about participants, is their Southampton Dupuytren's score, history and clinical symptoms and photographs of their hand. This information will be obtained at baseline (pre-surgical intervention), at radiation treatment planning, approximately 6 weeks after completion of all radiation and at 1 and 2 years following completion of radiotherapy.

Connect with a study center

  • University of Minnesota

    Minneapolis, Minnesota 55455
    United States

    Active - Recruiting

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