Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) Treatment

Key Inclusion Criteria:

1. Participants must meet protocol defined disease criteria requiring treatment fortheir respective disease prior to initiation of ibrutinib or acalabrutinib

2. Ibrutinib and acalabrutinib intolerance is defined as an unacceptable toxicitywhere, in the opinion of the investigator, treatment should be discontinued in spiteof optimal supportive care as a result of one of the following:

3. For ibrutinib and acalabrutinib intolerance events:

• 1 or more ≥ Grade 2 nonhematologic toxicities for >7 days (with or withouttreatment)
• 1 or more ≥ Grade 3 nonhematologic toxicity of any duration
• 1 or more Grade 3 neutropenia with infection or fever of any duration; or
• Grade 4 heme toxicity which persists to the point that the investigatorchose to stop therapy due to toxicity NOT progression.

2. For acalabrutinib intolerance events only;

• 1 or more ≥ Grade 1 nonhematologic toxicities of any duration with > 3recurrent episodes; or
• 1 or more ≥ Grade 1 nonhematologic toxicities for > 7 days (with orwithout treatment); or
• Inability to use acid-reducing agents or anticoagulants (eg, proton pumpinhibitors, warfarin) due to concurrent acalabrutinib use

3. Ibrutinib and/or acalabrutinib-related ≥ Grade 2 toxicities must have resolved to ≤Grade 1 or baseline prior to initiating treatment with zanubrutinib. Grade 1acalabrutinib-related toxicities must have resolved to Grade 0 or baseline prior toinitiating treatment with zanubrutinib.

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

5. Absolute neutrophil count (ANC) ≥ 1000/mm^3 with or without growth factor supportand platelet count ≥ 50,000/mm^3 (may be post-transfusion), on or prior to C1D1 ofzanubrutinib

Key Exclusion Criteria:

1. Clinically significant cardiovascular disease including the following:

2. Myocardial infarction within 6 months before the Screening

3. Unstable angina within 3 months before the Screening

4. New York Heart Association class III or IV congestive heart failure

5. History of sustained ventricular tachycardia, ventricular fibrillation, and/orTorsades de Pointes

6. QT interval corrected by Fridericia's formula > 480 milliseconds

7. History of Mobitz II second-degree or third-degree heart block without apermanent pacemaker in place

8. History of central nervous system (CNS) hemorrhage

9. Documented progressive disease (PD) during ibrutinib and/or acalabrutinib treatment.

10. Have received any anticancer therapy (other than immunotherapy) for CLL/SLL, WM,MCL, and MZL < 7 days before any Screening assessments are performed or anyimmunotherapy treatment, taken alone or as part of a chemoimmunotherapy regimen, < 4weeks before any Screening assessments are performed

11. Requires ongoing need for corticosteroid treatment > 10 mg daily of prednisone orequivalent corticosteroid. Note: Systemic corticosteroids must be fully taperedoff/discontinued ≥ 5 days before the first dose of study drug is administered.

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.