Dietary Nitrate and Erectile Dysfunction

Last updated: January 20, 2021
Sponsor: University Hospital, Essen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Erectile Dysfunction

Impotence

Infertility

Treatment

N/A

Clinical Study ID

NCT04116060
Nitrate E.D.
  • Ages 30-80
  • Male

Study Summary

An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion injury and hypertension. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet. Nitrate improves vascular functions in old adults and improves ischemia reperfusion injury in experimental models.

Whether dietary nitrate improves erectile dysfunction is not known and will be investigated in the present study.

Eligibility Criteria

Inclusion

Inclusion Criteria: Patients with erectile Dysfunction (IIEF5: 8-21) PDE-5 Inhibitors Responder Aged 30-80years

Exclusion

Exclusion Criteria:

  • Spinal cord disease
  • Insulin dependent Diabetes mellitus
  • Prostate cancer after operation, radiotherapy and hormone therapy
  • Treatment with NO-Donators or sGC-Activators
  • Chronic kidney disease (Stage IV-V)
  • Advanced liver dysfunction

Study Design

Total Participants: 40
Study Start date:
February 17, 2020
Estimated Completion Date:
August 01, 2021

Connect with a study center

  • University Hospital Essen

    Essen, NRW 45122
    Germany

    Active - Recruiting

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