Stereotactic Magnetic Resonance Guided Radiation Therapy

Inclusion Criteria:

• Participants must have a confirmed malignancy requiring stereotactic body radiationtherapy. See specific disease site cohorts for more details.

• Tumor size ≤ 7cm

• Age 18 years of older.

• ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)

• Ability to understand and the willingness to sign a written informed consentdocument.

• Specific eligibility requirements for each disease site with be covered in eachspecific cohort.

Exclusion Criteria:

• Specific exclusion requirements for each disease site with be covered in eachspecific cohort

• History of allergic reactions attributed to gadolinium-based IV contrast.

-- Note: If a patient will not receive contrast, this is not applicable

• Pregnant women are excluded from this study.

• Severe claustrophobia or anxiety

• Participants who cannot undergo an MRI