Long-term Follow-up of Cognitive and Functional Evolutions of Persons With Isolated Cognitive Complaints or Mild Cognitive Deficits

Last updated: February 14, 2025
Sponsor: University Hospital, Bordeaux
Overall Status: Completed

Phase

N/A

Condition

Dementia

Memory Loss

Mental Disability

Treatment

N/A

Clinical Study ID

NCT04111211
CHUBX 2019/16
  • Ages > 18
  • All Genders

Study Summary

Dementia is a clinical syndrome that is the result of distinct underlying pathologies including Alzheimer's disease (AD). Despite more than two decades of research on prevention and treatment of dementia and aging-related cognitive decline, highly effective preventive and therapeutic strategies remain elusive.

Many features of dementia render it especially challenging. Indeed development of disease occurs insidiously over the course of years or decade. In addition, the causes of dementia and determinants of its severity are likely multi-factorial.

To overcome these challenges and better understand the causes and course of AD and related disorders, long term follow-up studies of persons at high risk of dementia are required including multidimensional and harmonized assessment of risk factors, phenotypes (cognition, neuropsychiatric symptoms, physical health, self rated health) and endophenotypes (blood markers, genetic markers, neuroimaging markers).

This project proposes an extension of the follow-up of Memento participants over 5 to 10 years with of focus on cognitive outcomes and comorbidities.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants aged over 18 year-old

  • Being included in Memento cohort

  • Affiliated person or beneficiary of a social security scheme.

  • Participants capable of expressing non objection

  • Non objection expressed by the tutor for participants under tutorship

  • Non objection expressed by the participant assisted by their guardian forparticipants under guardianship

  • Non objection expressed by the trusted person (in accordance with art. L1111-6 ofCode de la Santé Publique) for participants without the capacity to expressnon-objection and who are not under legal protection measure

Exclusion

Exclusion Criteria:

  • Expressing opposition to participate in Memento-Plus

Study Design

Total Participants: 1028
Study Start date:
December 03, 2019
Estimated Completion Date:
December 20, 2024

Connect with a study center

  • CHU d'Amiens

    Amiens,
    France

    Site Not Available

  • AP-HP - CHU Avicenne

    Bobigny,
    France

    Site Not Available

  • CHU de Bordeaux - Pellegrin

    Bordeaux,
    France

    Site Not Available

  • CHU de Clermont-Ferrand

    Clermont-ferrand,
    France

    Site Not Available

  • Hôpitaux Civils de Colmar

    Colmar, 68000
    France

    Site Not Available

  • CHU de Dijon

    Dijon,
    France

    Site Not Available

  • CHU de Grenoble

    Grenoble,
    France

    Site Not Available

  • CHU de Lille

    Lille,
    France

    Site Not Available

  • AP-HM

    Marseille,
    France

    Site Not Available

  • CHU de Montpellier

    Montpellier,
    France

    Site Not Available

  • CHU de Nancy

    Nancy,
    France

    Site Not Available

  • CHU de Nantes

    Nantes,
    France

    Site Not Available

  • CHRU de Nice - Institut Claude Pompidou

    Nice,
    France

    Site Not Available

  • CHU de Nice - Hôpital de Cimiez

    Nice,
    France

    Site Not Available

  • AP-HP - Hôpital BROCA

    Paris,
    France

    Site Not Available

  • APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal

    Paris,
    France

    Site Not Available

  • Ap-Hp La Pitié-Salpêtrière

    Paris,
    France

    Site Not Available

  • CHU de Bordeaux

    Pessac,
    France

    Site Not Available

  • CHU de Poitiers

    Poitiers,
    France

    Site Not Available

  • CHU de Rouen

    Rouen,
    France

    Site Not Available

  • CHU de Saint-Etienne

    Saint-etienne,
    France

    Site Not Available

  • CHU de Strasbourg

    Strasbourg,
    France

    Site Not Available

  • CHU de Toulouse

    Toulouse,
    France

    Site Not Available

  • CHU de Toulouse - Hôpital Purpan

    Toulouse,
    France

    Site Not Available

  • CHU de Tours

    Tours,
    France

    Site Not Available

  • Hospice Civil de Lyon

    Villeurbanne,
    France

    Site Not Available

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