Evaluation of S-600918 in Adults With Refractory Chronic Cough

Key Inclusion Criteria:

• Having refractory chronic cough (including unexplained chronic cough) for at least 1year.
• If female and of childbearing potential, agreement to use one of the allowedcontraceptive methods.
• Capable of giving signed informed consent.

Key Exclusion Criteria:

• Currently smokes or uses potentially irritating inhalational agents (eg, e-cigarettes,smokeless cigarettes, vaping); stopped smoking or using potentially irritatinginhalational agents within the last year; or has a smoking history of 20 pack-years ormore.
• Has chronic obstructive pulmonary disease or uncontrolled asthma.
• Has a clinically unstable medical condition.
• History of or ongoing significant psychiatric disorder.
• History of respiratory tract infection or significant change in lung function or apulmonary condition in the last 4 weeks.
• History of malignancy in the last 5 years.
• History of severe drug allergy.
• History of alcohol or drug abuse in the last year or currently uses any form ofmarijuana or illicit drugs.
• Has a clinically significant finding on a chest x-ray or chest computed tomography (CT) scan in the last year.
• Has systolic blood pressure > 160 mm Hg or diastolic blood pressure > 90 mm Hg.
• Received S-600918 previously.
• Received an investigational drug in the last 3 months.
• Received an angiotensin converting enzyme (ACE) inhibitor in the last 3 months orrequires such treatment.
• Has a positive serologic test for human immunodeficiency virus (HIV) antigen orantibody, hepatitis B virus surface antigen, or hepatitis C virus ribonucleic acid (RNA).
• If female, pregnant or trying to become pregnant or breastfeeding.