Tc99m-MAA Bronchial Artery Injection During Bronchial Embolization for Pulmonary Mass Induced Hemoptysis for Dosimetry Planning

Last updated: October 9, 2024
Sponsor: Massachusetts General Hospital
Overall Status: Completed

Phase

1

Condition

Lung Cancer

Non-small Cell Lung Cancer

Lung Disease

Treatment

Tc99m-MAA

Clinical Study ID

NCT04105283
19-218
  • Ages > 18
  • All Genders

Study Summary

This research study will evaluate the administration of a particle called macro-aggregated albumin (MAA) labelled with the radiotracer technetium 99m (Tc99m) as a proxy to estimate the anticipated dose of radiation to tumor and adjacent structures.

Administration of this labeled MAA will not have a therapeutic benefit on the participant's cancer. Administration will help researchers determine if arterial administration of radiation may be feasible for lung cancer in the future.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects 18 years of age and older

  • Patients with known active lung cancer with a history of hemoptysis presenting forstandard of care bronchial artery embolization will be considered.

  • Patients must be presenting for secondary prophylaxis of hemoptysis.

  • If female, not of childbearing potential or negative serum β-hCG pregnancy testprior to CTA chest and radiotracer injection.

  • If female, not nursing.

  • Willing and able to understand and sign a written informed consent document.

  • Willing and able to undergo all study procedures

Exclusion

Exclusion Criteria:

  • Patients with current active hemoptysis

  • Any acute or chronic inflammatory disease or medical conditions that in theinvestigator's opinion may interfere with the study procedures or the interpretationof the study results.

  • Subjects who have exclusion criteria that would prevent them from receiving a CTscan or fluoroscopy, or administration of contrast.

  • History of allergic reactions or hypersensitivity attributed to compounds of similarchemical or biologic composition to macro-aggregated albumin

  • Patients with severe pulmonary hypertension.

  • Glomerular filtration rate < 30

  • Platelets < 30

  • INR > 3.0

Study Design

Total Participants: 8
Treatment Group(s): 1
Primary Treatment: Tc99m-MAA
Phase: 1
Study Start date:
August 01, 2020
Estimated Completion Date:
July 01, 2024

Study Description

This research study is a Pilot Study, which is the first time investigators are examining this study intervention.

As mentioned above, standard of care treatment for Stage III lung cancer includes chemotherapy and stereotactic body radiation therapy. However, arterial administration of radiation to these tumors may represent an alternative method of radiotherapy, with dose directly administered to the tumor. The potential radiation dose to the tumor and adjacent structures is not known.

This study aims to estimate the dose of radiation to tumor and adjacent structures in the chest via administration of a radiotracer called Tc99m-MAA. Tc99m-MAA is a particle that is used to assess blood flow distribution and has a similar size to the particles that are utilized for arterial delivery of radiation therapy, also called radioembolization. Tc99m-MAA is currently used to estimate radiation dosimetry prior to arterial radiotherapy administration for liver malignancies.

If this study is successful, the results will allow doctors to use the distribution of Tc99m-MAA to estimate radiation dose to tumors and adjacent structures in the setting of intra-arterial radiation therapy. This will provide information to plan future therapy with intra-arterial radioembolization for lung malignancies.

Connect with a study center

  • Massachusetts General Hospital Cancer Center

    Boston, Massachusetts 02114
    United States

    Site Not Available

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