A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity

Inclusion Criteria:

• Informed consent of parent(s) or legally acceptable representative of subject andchild assent, as appropriate obtained before any trial-related activities.Trial-related activities are any procedures that are carried out as part of thetrial, including activities to determine suitability for the trial

• Male or female, ages 12 to below 18 years at the time of signing informed consent

• BMI equal to or above 95th percentile OR equal to or above 85th percentile (ongender and age-specific growth charts (CDC.gov)) with 1 or more weight relatedcomorbidity (treated or untreated): hypertension, dyslipidaemia, obstructive sleepapnoea or type 2 diabetes

• History of at least one self-reported unsuccessful dietary effort to lose weight

For subjects with type 2 diabetes at screening the following inclusion criteria apply in addition:

• HbA1c equal to or below 10.0% (86 mmol/mol) as measured by central laboratory at screening

Exclusion Criteria:

• Prepubertal subjects (Tanner stage 1)

• History of type 1 diabetes

• A self-reported (or by parent(s)/legally acceptable representative where applicable)change in body weight above 5 kg (11 lbs) within 90 days before screeningirrespective of medical records

• Subjects with secondary causes of obesity (i.e., hypothalamic, monogenic orendocrine causes)

• For subjects with type 2 diabetes only: Uncontrolled and potentially unstablediabetic retinopathy or maculopathy. Verified by a fundus examination performedwithin the past 90 days prior to screening. Pharmacological pupil-dilation is arequirement unless using a digital fundus photography camera specified fornon-dilated examination