Augmented Effects of Virtual-reality Cycling Training on Upper Limb Motor Functions by NIBS in Patients With CP

Inclusion Criteria:

• Diagnosis of CP according to clinical criteria

• Age 5-20 years

• No use of botulinum toxin in the past 4 months

• No significant perceptual or communication disturbances

• No other peripheral or central nervous system dysfunction

• No active inflammatory or pathologic changes in upper limb joints during theprevious 6 months

• No active medical problems, such as pneumonia, upper gastrointestinal bleeding, orurinary tract infection

• No active problems of epilepsy and EEG without epileptiform discharge

Exclusion Criteria:

• Metabolic disorders, such as inborn error of metabolism, electrolyte, and endocrinedisorders

• Active infectious disease, such as meningitis and encephalitis

• Patients with active medical problems, such as pneumonia, upper gastrointestinalbleeding, or urinary tract infection

• Poor compliance or intolerance for the TMS therapy

• Subjects with metallic implants or pregnancy.

• EEG show epileptiform discharge

• Patients with family history of epilipsy

• Patients with symptoms that are restricted from tDCS, such as epilepsy, migraine andunstable health condition