Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer

Inclusion Criteria:

• Pathologically confirmed malignancy

• Clinical or pathologic evidence of metastatic disease

• A site of malignant disease causing symptoms, or for which symptoms are imminent, inwhich radiation may be used for relief or prophylaxis

• Participants of child-bearing potential must agree to use adequate contraceptivemethods (e.g., hormonal or barrier method of birth control; abstinence) prior tostudy entry. Should a woman become pregnant or suspect she is pregnant while she orher partner is participating in this study, she should inform her treating physicianimmediately

• Participants with synchronous primary malignancies must have either: 1) documentedcontrol of their second malignancy or 2) have pathological confirmation of themetastatic lesion/disease site being targeted

• Participant must be willing and able to participate in protocol requirements,including pre- and post-treatment survey evaluations and clinical assessments

• Participant must understand the investigational nature of this study and sign anIndependent Ethics Committee/Institutional Review Board approved written informedconsent form prior to receiving any study related procedure

Exclusion Criteria:

• Prior radiation therapy targeting the same area for which radiation treatment isbeing planned (i.e., re-irradiation to a specific site of metastatic disease)

• Participants with known brain metastases

• Pregnant or nursing female participants

• Participants who are unable to accurately or reliably recount their pain medicationregimens, including type, amount, or frequency of pain medication usage

• Participants who require or are being planned for surgical stabilization ormetastasectomy of the planned radiation site

• Severe, active co-morbidity defined as follows:

• Unstable angina and/or congestive heart failure requiring hospitalizationwithin the last 3 months;

• Transmural myocardial infarction within the last 3 months;

• Acute bacterial or fungal infection requiring intravenous antibiotics at thetime of registration;

• Chronic obstructive pulmonary disease exacerbation or other respiratory illnessrequiring hospitalization or precluding study therapy at the time ofregistration

• Unwilling or unable to follow protocol requirements

• Any condition which, in the investigator?s opinion, deems the patient unable toparticipate in enrollment

• Adults unable to consent

• Individuals who are not yet adults (infants, children, teenagers)

• Pregnant women

• Prisoners