Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura

Inclusion Criteria:

• Diagnosis of migraine with aura code

• At least 1 aura with aura per month in the 3 months prior to inclusion

• No prophylactic antimigraine treatment for at least 1 month prior to inclusion

• For women of childbearing age, use of a reliable contraceptive method at least 3months before and 1 month after the study

• Signature of written informed consent

• Patient affiliated with Social Security

Exclusion Criteria:

• Existence of contraindication to taking amiloride:

• Known hypersensitivity to the molecule

• Hyperkalemia (potassium level (> 5.5 mmol / l))

• Use of another hyperkalemic diuretic or potassium salts

• Renal insufficiency (clearance <60 ml / min)

• Severe hepatocellular insufficiency

• In combination with lithium, converting enzyme inhibitors, angiotensin IIinhibitors (except if there is hypokalemia), ciclosporin, tacrolimus,non-antiarrhythmic drugs giving torsades de pointes

• Cardiovascular and renal history, for subjects over 75 years old

• Patient, who from an investigator's point of view would not be compliant to theprocedure of the study

• Pregnant or lactating patient

• Patient under trusteeship, under guardianship, protected by law