Gemcitabine and Docetaxel With Radiation in Adults With Soft Tissue Sarcoma of the Extremities

Inclusion Criteria:

• Patients must have a histologically or cytologically confirmed Grade II or III softtissue sarcoma that is considered to be resectable and are candidates for pre-opradiation.

• Age greater than or equal to 18 years. No children will be enrolled on thisprotocol.

• Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to

• Women of child-bearing potential and men must agree to use adequate contraception (hormonal or double-barrier method of birth control; abstinence) prior to studyentry and for the duration of study participation. Should a woman become pregnant orsuspect she is pregnant while participating in this study, she should inform hertreating physician immediately.

• Ability to understand and the willingness to sign a written informed consentdocument.

Exclusion Criteria:

• Patients taking concurrent hormonal therapy, biologic or other chemotherapy areexcluded except women on hormonal contraceptives.

• Patients taking an investigational agent are excluded.

• Pregnant and nursing women are excluded.

• Patients who require amputation for local control.

• Patients who underwent unplanned excision or other previous surgery involving theaffected extremity.

• Patients with sarcoma subtypes for which established chemotherapeutic regimensexist.

• History of radiation to the limb.