Triamcinolone With Vitamin D Synergistic Efficacy in Psoriasis

Inclusion Criteria:

• Age 18 and older

• Mild to severe plaque psoriasis (2% or greater Body Surface Area; Psoriasis Area andSeverity Score of 2 or greater; Investigator Grade Assessment of mild-severe)

Exclusion Criteria:

• Currently taking medication that alters the normal ion balance of low-dose in blood.

• No calcium supplements 1 month prior to baseline (not including multivitamins).

• Unstable or uncontrolled illness, including but not limited tocerebro-cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine,hematologic, neurologic or psychiatric disease at screening.

• Abnormal laboratory values at screening, that in the opinion of the investigator,would potentially affect patient safety or data integrity.

• Not on systemic non-biologic therapy (including, but not limited to, oral psoralenplus ultraviolet A [photochemotherapy (PUVA)] light therapy; cyclosporine;corticosteroids; methotrexate; oral retinoids; apremilast; tofacitinib;mycophenolate mofetil; thioguanine; hydroxyurea; sirolimus; tacrolimus;azathioprine; leflunomide; fumaric acid derivatives; or 1, 25 dihydroxy vitamin D3and analogues) within 28 days prior to baseline.

• No phototherapy (including either oral and topical PUVA light therapy, ultravioletB, excimer laser, or self-treatment with tanning beds or therapeutic sunbathing)within 28 days prior to baseline.

• No topical treatment (including, but not limited to, corticosteroids [upper midstrength or lower potency topical steroids are permitted on the intertriginous areasand face], crisaborole, anthralin, calcipotriene, topical vitamin D derivatives,retinoids, tazarotene, pimecrolimus, tacrolimus, emollients and othernonprescription topical products containing urea, >3% salicylic acid, alpha- orbeta-hydroxyl acids, or medicated shampoos [for example those that contain >3%salicylic acid, corticosteroids, coal tar, or vitamin D3 analogues]) within 14 daysprior to baseline.

• No biologic agents within 8 weeks or three half-lives, whichever is greater prior tobaseline.

• History of renal impairment.

• History of renal stones.

• History of parathyroid abnormalities

• Osteoporosis

• History of severe arthritis

• Ongoing use of tanning bed or other UV device or excessive sunlight

• Unable to understand/complete informed consent.