Correlations Between Oxidative Stress Biomarkers, h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI

Last updated: July 27, 2019
Sponsor: Grigore T. Popa University of Medicine and Pharmacy
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stress

Coronary Artery Disease

Hypercholesterolemia

Treatment

N/A

Clinical Study ID

NCT04034940
OxiSTEMI01
  • Ages > 18
  • All Genders

Study Summary

The investigators intend to evaluate Oxidative Stress biomarkers through a. Catalase Activity Assay; b. Lipid Peroxidation Assay; c. SOD Assay; d. Total Antioxidant Capacity Assay; e. Glutathione Peroxidase at patients with acute myocardial infarction STEMI referred for primary PCI; The investigators also aim to evaluate cardiac necrosis by measuring Heart Fatty Acid Binding Protein (H-FABP), TnI, CK, CK-MB, LDH and AST in these patients with acute myocardial infarction referred for primary PCI; Also, the investigators intend to evaluate body composition through bioimpedance spectroscopy (BCM - Fresenius Care) at the moment of admission.

The investigators aim to fully characterise these patients through oxidative millieu, hFABP and make correlations with LVEF dysfunction.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adults with ST elevation Myocardial Infarction (<12h) diagnostic confirmed;

  • Included in the Romanian National Programme of Primary Percutaneous Revascularisation (for who the Guidelines recommend primary PCI);

Exclusion

Exclusion Criteria:

  • Patients who do not sign informed consent for primary PCI

Study Design

Total Participants: 200
Study Start date:
August 01, 2019
Estimated Completion Date:
August 31, 2020

Study Description

Gathered data:

  • Descriptive general demographic data;

  • Previous pathologies (ischemic heart disease, peripheral arterial disease, stroke, heart failure, previous percutaneous coronary interventions, coronary artery bypass grafting - CABG, known renal disease);

  • Cardiovascular risk factors (age, weight, height, abdominal perimeter, body mass index, smoking, sedentariness, diabetes, hypertension, dyslipidaemia);

  • Oxidative Stress biomarkers: Catalase Activity Assay; Lipid Peroxidation Assay; SOD Assay; Total Antioxidant Capacity Assay; Glutathione ;

  • Cardiac necrosis markers: Heart Fatty Acid Binding Protein (H-FABP), TnI, CK, CK-MB, LDH and OGT;

  • Routine biological data;

  • Metabolic data (obtained from two body composition monitoring evaluations - before and 12 hours after coronary intervention) - body water, body fat tissue;

  • Information regarding primary PCI (less than 12 hours of ischemic symptoms);

  • Coronarographic details, type of used stent, periprocedural specific complications, final TIMI - thrombolysis in myocardial infarction - flow);

  • Echocardiography at admission (LVEF);

  • Measurement of arterial stiffness through Sphigmocore pulsed-wave-velocity (24 hrs post-procedural, 2 velocities: carotid - femoral and carotid - radial);

  • Calculating of cardiovascular risk scores: Syntax Score, Framingham score, ASSIGN score, QRISK2 score, PROCAM score, CRUSADE score, GRACE score, CHADS VASc score, MESA score, ASCVD score, Hamilton Depression Rating Scale (HAM-D), Hamilton Rating Scale for Anxiety;

  • In-hospital and one month follow-up MACE.

Connect with a study center

  • Cardiovascular Diseases Institute Iasi

    Iaşi, Iasi 700503
    Romania

    Active - Recruiting

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