Comparison of Effectiveness of Amniotic Membrane and Duoderm Dressings in Pediatric Burns

Last updated: August 31, 2020
Sponsor: King Edward Medical University
Overall Status: Completed

Phase

2/3

Condition

Hyponatremia

Skin Wounds

Treatment

N/A

Clinical Study ID

NCT04030754
257/RC/KEMU
  • Ages 1-12
  • All Genders

Study Summary

There is a difference in frequency of wound infection, mean pain score, mean of time for skin grafting and hospital stay in pediatric 2nd and 3rd degree burns, between amniotic membrane and duoderm dressings

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 10-45 % percent 2nd and 3rd degree fresh burns age less than 12 years patients of bothgender

Exclusion

Exclusion Criteria:

  • patients whose parents are not willing patients whose wound c/s comes positive at thetime of admission patients who have associated medical disorder and trauma.

Study Design

Total Participants: 172
Study Start date:
November 01, 2018
Estimated Completion Date:
February 14, 2020

Study Description

After informed consent of the patients, patients who will fulfill the inclusion and exclusion criteria will be enrolled in the study from Department of Pediatric Surgery, Mayo Hospital Lahore and will be randomly allocated by lottery method into 2 groups by the doctor. Group A and B with 86 patients in each group. Group A patients will be undergoing amniotic membrane dressing, while group B patients will undergo colloid gel foam dressing. Basic demographic information will be noted. Effect modifiers (hemoglobin level, weight and height) will be noted.

In group A, the wounds will be washed with normal saline and then covered with amniotic membrane over which a layer of Vaseline gauze will be applied and dressing with gauze and the crape bandage will be applied. Every 3-4 days these dressings will be changed and assessed for pain, wound infection and wound c/s will be sent. Placentas from clean vaginal deliveries and elective C-sections will be taken. Blood of mother will be screened. Amniotic membrane will be separated from placenta in a clean sterile bowl. Bowl will be put in refrigerator at 4 degrees.

In group B, wound will be washed with normal saline . The wound site will be covered with Colloid Gel Foam and gauze, and crape bandage will be applied. Dressing will be changed after 3-4 days. The outcome (pain score, wound infection,time for skin grafting and hospital stay) will be compared in both groups.

Connect with a study center

  • King Edward Medical University

    Lahore, Punjab 54000
    Pakistan

    Site Not Available

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