The Efficacy of Cimetidin for Acute - Extrinsic Atopic Dermatitis Treated With Standard Therapy

Phase

Condition

Allergy

Eczema (Atopic Dermatitis)

Atopic Dermatitis

Treatment

N/A

Clinical Study ID

NCT04018131

0071

Ages 12-60
All Genders

Study Summary

Extrinsic - atopic dermatitis is characterized by increased of IgE serum levels. Acute extrinsic - atopic dermatitis is a type 1 hypersensitivity that involve various inflammatory mediator including Interleukin-4, Interleukin-12, and Interferon-Ɣ. Recent treatment of atopic dermatitis mainly focused on reducing the inflammation through topical and systemic regiments. However, no systemic medication could control the atopic dermatitis remission yet, and the current immunosuppressive agent used may cause many side effects if administered on a long term basis.

In the future, treatment of atopic dermatitis were specifically targeted to inhibit the role of Th2. Cimetidine is H2 receptor antihistamine that has been widely used as gastrointestinal medication for a long time. Cimetidine could modulate the immune system by activating the Th1 and lowering the Th2 activity, and lowering the IgE levels thus reducing the severity of atopic dermatitis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Atopic dermatitis patients diagnosed with Hanifin Rajka criteria
Acute extrinsic atopic dermatitis
IgE levels above 200 IU/mL
Minimum weight 15kg

Exclusion

Exclusion Criteria:

Consumption of corticosteroid and systemic immunosuppressant within the last 2 weeks
Chronic lesion
Consumption of drugs that reacts with cimetidine
Disturbance in lab results including complete blood count, liver function, and renalfunction.
Other conditions that might increase IgE levels

Study Design

March 26, 2018

June 30, 2020

Study Description

The aim of this study is to measure the efficacy of cimetidine for acute, extrinsic-atopic dermatitis treated with standard therapy using SCORAD as the clinical outcome. This study also measure Immunoglobulin E, Interleukin-4, Interleukin-12, and Interferon-Ɣ serum levels before and after treatment.

Connect with a study center

Faculty of Medicine Universitas Indonesia
Jakarta Pusat, Jakarta 10430
Indonesia
Active - Recruiting

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