48-hour Ambulatory EEG Monitoring in Early Onset Alzheimer's Disease

Inclusion criteria for EOAD patients will be recruited from the LEADS trial with the following:

• 40 to 64 years of age

• Meets NIA-AA criteria for mild cognitive impairment (MCI) due to AD or probable ADdementia.

• Have a global CDR score of ≤ 1.0

• Have capacity to provide informed consent (ICF) or has a legal authorizedrepresentative or guardian who provides IC.

• Amyloid positive status (PET scan with evidence of elevated amyloid)

• Must have a study partner (informant) who spends a minimum average of 10 hours perweek with the participant (e.g., family member, significant other, friend, andcaregiver) who is generally aware of the participants' daily activities and canprovide information about the participant's cognitive and functional performance. Ifthe participant does not have a study partner who spends 10 face-to-face hours perweek, other arrangements for identifying a viable study partner will be granted on acase-by-case basis by the Site PI.

• Not pregnant or lactating. Women must be two years post-menopausal, be surgicallysterile, or have a negative pregnancy test prior to each PET scan

• Fluent in English.

Exclusion Criteria:

• Meets core clinical criteria for non-AD dementia.

• Two or more first degree relatives with a history of EOAD suggestive of autosomaldominant transmission, unless known pathogenic mutations in APP, PSEN1, PSEN2 havebeen excluded.

• Known mutation in an ADAD gene (APP, PSEN1, PSEN2) or other autosomal dominant genesassociated with other neurodegenerative disorders.

• MRI scans with evidence of infection or focal lesions, cortical strokes, multiplelacunes (single lacune is allowable unless it meets criteria for strategic lacuneaffecting cognition)

• Any significant systemic illness or unstable medical condition, which could lead todifficulty complying with the protocol (at the discretion of the Site PI)

• Medical history of a brain disorder other than the disorder causing dementia exceptfor headache.

• Deemed ineligible by the Site PI for any other reason.