MRI Assessment of Pulmonary Edema in Acute Heart Failure

Last updated: July 1, 2024
Sponsor: University of Alberta
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Failure

Congestive Heart Failure

Lung Injury

Treatment

MRI

Clinical Study ID

NCT03999138
Pro00091033
  • Ages > 18
  • All Genders

Study Summary

Researchers are testing a more accurate way to measure how much fluid is in the lungs (also called pulmonary edema, or "increased lung water") in people with Heart Failure (HF) using MRI (Magnetic Resonance Imaging). There is little known about the exact level of lung water in patients with AHF or how these levels change from the time of hospital admission to discharge. The purpose of this research study is to measure the lung water in patients hospitalized for HF, to determine the change in lung water over the course of hospitalization and treatment, and to find out if lung water levels can predict if patients are higher or lower risk for returning to the hospital or dying from heart failure.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years of age or older and willing/able to provide informed consent

  • patients being treated for acute heart failure (including those patients with bothreduced and preserved ejection fraction)

  • patients receiving medical therapy for pulmonary edema by current standard of care (including oral or IV diuretics)

  • patients identified within 48 hours of initiation of medical therapy for pulmonaryedema, defined as the time of first diuretic (IV or PO) or escalation of existingdiuretic therapy administered within the ED or hospital

Exclusion

Exclusion Criteria:

  • contraindication to MRI

  • patient too critically ill/unstable as per the clinical care team for transport toMRI scanner within the required scanning window

  • moderate to severe dementia

Study Design

Total Participants: 300
Treatment Group(s): 1
Primary Treatment: MRI
Phase:
Study Start date:
January 02, 2019
Estimated Completion Date:
June 01, 2025

Study Description

Heart failure is a condition where the heart is unable to pump enough blood to meet the body's needs and Acute Heart Failure is a sudden worsening of this condition. It is associated with many symptoms but most commonly includes shortness of breath due to pulmonary edema (or increased "lung water").

A physical exam and chest x-ray are commonly used to diagnose AHF and estimate the amount of increased lung water in patients with AHF. This study will use images from MRI (Magnetic Resonance Imaging) scans to obtain a more accurate measurement of the increased lung water in AHF patients. Lung water will be measured via MRI at hospital admission and discharge to find out the change in lung water over the course of hospitalization and treatment. The investigators will collect NT-proBNP and perform a chest x-ray upon hospital admission and again upon discharge, if not already done as part of usual care. The investigators will follow medical records for up to 5 years after hospitalization to see if the accurate lung water measurements obtained in hospital can predict long term outcomes. This is a multi-centre project and a total of 300 patients will be recruited to participate.

Connect with a study center

  • University of Alberta

    Edmonton, Alberta
    Canada

    Site Not Available

  • University of Ottawa Heart Institute

    Ottawa, Ontario
    Canada

    Active - Recruiting

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