Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects

Last updated: February 16, 2026
Sponsor: Universidad de Murcia
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

NIPSA plus connective tissue graft

NIPSA (Non-incised papilla surgical approach)

Clinical Study ID

NCT03997578
CEI 1864/2018 - CBE 100/2018
  • Ages > 18
  • All Genders

Study Summary

The present study pretends to show the results of combining a modification of the Non-incised papillae surgical approach (NIPSA) attempting to improve the outcome in the treatment of teeth with advanced periodontal support loss.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients diagnosed with periodontitis.

  • plaque index and bleeding index of < 30%.

  • periodontal lesions with pocket probing depth > 5 mm.

  • intrabony defect > 3 mm.

  • intrabony defect configuration including a 1 and/or 2-wall component, alwaysinvolving the buccal wall.

Exclusion

Exclusion Criteria:

  • patients with systemic diseases that contraindicated treatment.

  • third molars.

  • teeth with incorrect endodontic or restorative treatment.

Study Design

Total Participants: 40
Treatment Group(s): 2
Primary Treatment: NIPSA plus connective tissue graft
Phase:
Study Start date:
September 03, 2019
Estimated Completion Date:
February 02, 2027

Connect with a study center

  • Centro Odontologico Del Sureste Slp

    Murcia, 30007
    Spain

    Site Not Available

  • Centro Odontologico Del Sureste Slp

    Murcia 2513416, 30007
    Spain

    Active - Recruiting

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