Continuous Serrates Plane Block in Axillary Dissection

Last updated: June 19, 2019
Sponsor: Arcispedale Santa Maria Nuova-IRCCS
Overall Status: Active - Recruiting

Phase

N/A

Condition

Breast Cancer

Cancer

Treatment

N/A

Clinical Study ID

NCT03992859
CIMPAX BREAST
  • Ages 18-80
  • Female

Study Summary

Patients undergone to axillary dissection during breast surgery with a PECS I, II block will be randomized to receive either a serratus plane continuous local anesthetic infusion through a multiple hole catheter or nothing. Both groups will receive a patient controlled analgesia with morphine.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age > 18

  • breast surgery

  • informed consent

Exclusion

Exclusion Criteria:

  • ASA >3

  • allergy to local anesthetic

  • opioid administration in the last month

  • patient refusal

Study Design

Total Participants: 84
Study Start date:
June 13, 2018
Estimated Completion Date:
June 13, 2020

Study Description

84 patients ASA I-III undergoing breast surgery with axillary dissection after modified PECS II block as described by Blanco et al. with Ropivacaine 0.37% 30 ml. General anesthesia with remifentanil 0.1 mcg/Kg/min and Propofol 1.5-2 mg/Kg to facilitate endotracheal intubation will provide for all patients, and maintained with Desflurane and Remifentanil infusion. In case of axillary dissection patient will be randomized to receive either a serratus plane continuous local anesthetic infusion through a multiple hole catheter or nothing. Both groups will receive as intraoperative analgesia 1 g Acetaminophene ev 30 minute before the end of the surgery and 1g. 8h-1 postoperative associated to a patient controlled analgesia with morphine. PCA will set up as follow: bolus 1 mg, lock-out 6 minute, max 20 mg/4h. In the serratus group 10 ml of Ropivacaine 0.5% before fascial closure and a continuous infusion of 12 ml/h of Ropivacaine 0.2% will be provide.

Connect with a study center

  • Ausl-Irccs Reggio Emilia

    Reggio Emilia, RE 42120
    Italy

    Active - Recruiting

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