Effect of Vitamin D on the Size of Fibroids in Women With Vitamin D Deficiency

Last updated: March 11, 2025
Sponsor: Fundación IVI
Overall Status: Completed

Phase

N/A

Condition

Sarcoma (Pediatric)

Uterine Fibroids

Desmoid Tumors

Treatment

N/A

Clinical Study ID

NCT03991078
IIS-COL-2018-01
1812-FIVI-100-AP
  • Ages 18-45
  • Female

Study Summary

Vitamin D supplementation in patients with uterine fibroids who present hypovitaminosis D to re-establish their normal serum values could stabilize the size of the uterine fibroids and thus prevent their growth or reduce their size thanks to the anti-proliferative action of Vitamin D on the myoma cells.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed with at least one fibroid > 3 cm

  • With hypovitaminosis D (25(OH)D < 30 ng/ml)

  • BMI < 30

  • No hormonal treatment in the 3 months prior to the ultrasound study

Exclusion

Exclusion Criteria:

  • Black race

  • Symptomatic fibroids subsidiary to hormonal or surgical treatment

  • Desire of gestation in the next 6 months

  • Presence of degenerating adenomyosis or fibroids

  • Treatment with sexual hormones: mifepristone, aGnRH or any other medication that mayinterfere with fibroids.

  • History of neoplasia of gynecological origin and/or existence of uterinemalformations.

  • Hypercalcemia or abnormal liver or kidney function is present

Study Design

Total Participants: 15
Study Start date:
July 09, 2019
Estimated Completion Date:
December 25, 2024

Connect with a study center

  • Fundacion IVI

    Valencia, 46026
    Spain

    Site Not Available

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