Recovery of Consciousness Following Intracerebral Hemorrhage

Phase

N/A

Condition

Brain Injury

Stroke

Hemorrhage

Treatment

N/A

Clinical Study ID

NCT03990558

AAAS3574

1R01NS106014-01A1

Ages > 18
All Genders

Study Summary

The objectives of the RECONFIG clinical study are to :

To identify the time to the first diagnosis of cognitive motor dissociation (CMD) in intracerebral hemorrhage (ICH) patients and to investigate whether these patients will clinically follow commands earlier after the hemorrhage.
To determine whether CMD independently predicts long term functional outcomes (6-month mRS scores) in ICH patients, and is associated with long term cognitive and quality of life outcomes.
To determine the EEG response to verbal commands of the motor imagery paradigm between patients with and without sensory aphasia.

The overall goal is to determine predictors and the trajectory of neurological recovery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

18 years or older.
Diagnosis of primary ICH (i.e., related to hypertension or anticoagulants) on HeadCT and/or MRI in the frontal lobe, thalamus, or striatocapsular region.
Unresponsive to commands within 48 hours after onset of the bleed.
English, Spanish or, French as the primary language.

Exclusion

Exclusion Criteria:

Major bleeding in the cortex outside of the frontal lobe, cerebellum, or brainstem (judged as a cause for unconsciousness as per the attending neurointensivist).
Other causes of ICH or different types of acute brain injury (e.g., traumatic braininjury).
Severe cardiorespiratory compromise and similar acutely life-threatening conditionsat the time of enrollment.
Evidence of pre-morbid aphasia or deafness.
Unconscious prior to ICH.
Pregnancy.
Prisoners.
Health care proxy decides against study participation or decided for withdrawal oflife sustaining therapies.

Study Design

June 15, 2019

March 31, 2031

Study Description

Unconsciousness is common after an acute brain injury such as a brain hemorrhage, and recovery is poorly understood. This lack of knowledge is a key impediment to the development of novel strategies to improve outcomes and is one of the main reasons that prognostication of recovery of consciousness and functional outcomes is inaccurate. One-fifth of clinically unconscious patients with acute brain injury are able to follow commands using a simple, bedside EEG motor imagery test that directly measures brain activity associated with the attempt to move. This state is called cognitive motor dissociation (CMD). Pilot data indicate that CMD patients are more likely to clinically recover consciousness and have better longterm functional outcomes than non-CMD patients. To integrate these findings into clinical practice, there is a need to better understand the trajectory of CMD. This will only be possible in a tightly-controlled study with a homogenous patient cohort that is well characterized early after the injury and captures long-term outcomes.

RECONFIG is a multicenter, prospective, cross-sectional observational study in patients who have a clinical diagnosis of intracerebral hemorrhage and that are unresponsive at the time of enrollment. One hundred and fifty subjects will be recruited over 4 years at 2 sites. Subjects will be assessed with behavioral measures and MRI during the acute hospitalization. Patients will be followed for 6 months to determine the functional outcome (primary outcome measure). Additionally, the investigator will study conscious intracerebral hemorrhage patients with intracerebral hemorrhage and aphasia to determine the impact of aphasia.

Connect with a study center

University of Miami and Jackson Health System (UM/JHS)
Miami, Florida 33136
United States
Active - Recruiting
Columbia University Medical Center
New York, New York 10032
United States
Active - Recruiting

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