Exercise Treatment With Standard Therapy for Metastatic Breast Cancer

Last updated: August 26, 2025
Sponsor: Memorial Sloan Kettering Cancer Center
Overall Status: Active - Not Recruiting

Phase

1

Condition

N/A

Treatment

Exercise Treatment

Clinical Study ID

NCT03988595
19-113
  • Ages > 19
  • Female

Study Summary

This study will test any good and bad effects of aerobic exercise performed while you are receiving the usual first-line treatment for metastatic breast cancer. The researchers think that exercise helps delay the development of resistance to hormone therapy while slowing the growth of tumors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with histologically-confirmed, HR-positive (ER and/or PR), HER2-negativemetastatic breast cancer (MBC)

  • Postmenopausal status defined by lack of menses for 2 years, oophorectomy, ormedical ovarian suppression

  • Receiving first line endocrine-based therapy (tamoxifen, aromatase inhibitor, orfulvestrant; concurrent molecular therapy also allowed)

  • Sedentary (i.e., <60 minutes / week of exercise)

  • Age >18 years

  • BMI ≥ 18.5

  • Cleared for exercise participation as per screening clearance via PAR-Q+

  • Cleared for study participation as per screening consultation with an MSK ExercisePhysiologist

  • Willingness to comply with all study-related procedures

  • Patients with "treated and stable" brain lesions of a duration of ≥ 2 months may beenrolled

Exclusion

Exclusion Criteria:

  • Life expectancy <6 months

  • Enrollment onto any other therapeutic investigational study

  • Mental impairment leading to inability to cooperate

  • Concurrent participation in weight loss or other exercise programs

Study Design

Total Participants: 54
Treatment Group(s): 1
Primary Treatment: Exercise Treatment
Phase: 1
Study Start date:
June 12, 2019
Estimated Completion Date:
August 01, 2026

Connect with a study center

  • Indiana University (Data Collection Only)

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Indiana University (Data Collection Only)

    Indianapolis 4259418, Indiana 4921868 46202
    United States

    Site Not Available

  • Johns Hopkins Hospital (Data Collection Only)

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Johns Hopkins Hospital (Data Collection Only)

    Baltimore 4347778, Maryland 4361885 21287
    United States

    Site Not Available

  • Memoral Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey 07920
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • Memoral Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey 07748
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey 07748
    United States

    Site Not Available

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey 07645
    United States

    Site Not Available

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge 5095409, New Jersey 5101760 07920
    United States

    Site Not Available

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown 5101170, New Jersey 5101760 07748
    United States

    Site Not Available

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale 5101361, New Jersey 5101760 07645
    United States

    Site Not Available

  • Montefiore Health Systems (Montefiore Medical Center) (Data Collection Only)

    Bronx, New York 10467
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center @ Suffolk (Limited protocol activity)

    Commack, New York 11725
    United States

    Site Not Available

  • Memoral Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York 10604
    United States

    Active - Recruiting

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York 11553
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center @ Suffolk (Limited protocol activity)

    Commack 5113412, New York 5128638 11725
    United States

    Site Not Available

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison 5120095, New York 5128638 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York 5128581, New York 5128638 10065
    United States

    Site Not Available

  • Montefiore Health Systems (Montefiore Medical Center) (Data Collection Only)

    The Bronx 5110266, New York 5128638 10467
    United States

    Site Not Available

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale 5141927, New York 5128638 11553
    United States

    Site Not Available

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