TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection

Inclusion Criteria:

• Subjects may be included in the study if they meet all of the following inclusioncriteria:
• Males or females, 18 years of age or older;
• ABSSSI suspected or confirmed to be caused by gram-positive pathogens, including:
• Cellulitis/erysipelas;
• Wound infection;
• Major cutaneous abscess;
• Lesion with a minimum surface area of 75 cm2;
• Capable of giving signed informed consent.

Exclusion Criteria:

• Subjects will be excluded from the study if any of the following exclusion criteriaapply prior to randomization:
• History or hypersensitivity or intolerability to any fluoroquinolone, rifamycinor glycopeptide classes;
• ABSSSI suspected or confirmed to be caused by pathogens that are resistant to theglycopeptide class;
• Prior administration of systemic antibacterial therapy within 96 hours beforerandomization;
• ABSSSI with suspected or confirmed infection caused by gram-negative or anaerobicorganisms;
• ABSSSI with suspected or confirmed infection caused by fungal, mycobacterial,parasitic, or viral pathogens;
• Evidence of significant hepatic, hematologic, or immunologic disease;
• History or evidence of severe renal disease.