Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western Medicine

Inclusion Criteria:

• Girls are diagnosed as Idiopathic central precocious puberty by GnRH （gonadotrophinreleasing hormone）Stimulation Test, and their age of onset ≤8 years;
• Tanner stages of breast in female patients ≥ Tanner III stage，diameter of mammillarynucleus ≥ 3cm;
• B-type ultrasonography: the volume of uterus≥3ml, the volume of ovary≥1.5ml, thediameter of follicle≥4mm;
• Bone age: compared the chronological age, the bone age is more than 1 year and thebone age <11.5 years old;
• It progresses rapidly, ratio of bone age difference to chronological age difference> 1;
• No GnRH analogs or sex hormones were administrated in the past;
• All above are needed at the same time.

Exclusion Criteria:

• Precocious precocity caused by the central nervous system organic diseases;
• Precocious precocity caused by congenital hypothyroidism, congenital adrenalhyperplasia, adrenal tumor and ovarian or testicular neoplasms as well asMcCune-Albright syndrome, etc;
• Precocious precocity with a family history of diseases such as tumor, leukemia,diabetes, systemic lupus erythematous;
• Pseudo sexual precocity and partial precocious puberty.