Sterotactic Operation Integrating With Thrombolysis in Basal Ganglion Hemorrhage Evacuation

Inclusion Criteria:

1. Diagnosis of spontaneous basal ganglia hemorrhage by imaging (CT, CTA, etc.) with avolume < 30 mL calculated by ABC/2 formula and Glasgow Coma Scale score ≥ 9.
2. With dysfunction such as hematoma-related motor aphasia, sensory aphasia, hemiplegiclimb muscle strength ≤ grade 3 or NIHSS score ≥ 15 points.
3. Hematoma stability shown by a CT scan at least 6 hours after the diagnostic CT (hematoma volume increase < 5 ml by ABC/2 formula)
4. Diagnostic CT scan should be obtained within 24 hours after the onset of symptoms.Cases with unclear onset time should be excluded.
5. Randomization within 72 hours after diagnostic CT.
6. Surgery should be performed within 72 hours after onset.
7. SBP <180 mmHg maintained for 6 hours prior to randomization.
8. Age between 18-70 years old.
9. mRS score ≤ 1 in past medical history.
10. Patients who are suitable and willing to be randomized to "puncture aspiration +urokinase" or conservative medical treatment.

Exclusion Criteria:

1. Hematoma involves other structures such as the thalamus and midbrain.
2. Mass effect or hydrocephalus due to intraventricular hemorrhage.
3. Imaging-based diagnosis of cerebrovascular abnormalities such as ruptured aneurysm,arteriovenous malformation (AVM) and moyamoya disease as well as hemorrhagictransformation of ischemic infarct and recent recurrence (within 1 year) of cerebralhemorrhage.
4. Manifestation of early stage cerebral herniation such as ipsilateral pupil changes andmidline shift exceeding 1 cm.
5. Patients with unsteady hematoma or with progression to intracranial hypertensionsyndrome.
6. Patients with any irreversible coagulopathy or known coagulation disorders; plateletcount <100,000; INR > 1.4.
7. Patients requiring long-term use of anticoagulants.
8. Patients taking dabigatran, apixaban and/or rivaroxaban (or similar drugs of the samecategory) before symptoms arise.
9. Bleeding in other sites, including retroperitoneal, gastrointestinal, genitourinary orrespiratory tract bleeding; superficial or skin surface bleeding mainly occurring inthe vascular puncture site or transvenous approach (eg. arterial puncture, venousincision, etc. ) or in the recent surgical site.
10. May be pregnant in the near future or already pregnant.
11. Previously enrolled in this study.
12. Participating in other interventional medical research or clinical trials at the sametime. Patients enrolled in observational, natural history and/or epidemiological studies (without intervention) are eligible for this trial.
13. Patients with an expected survival of less than 6 months.
14. Patients with severe co-morbidity (including hepatic, renal, gastrointestinal,respiratory, cardiovascular, endocrine, immune and/or hematological disorders) whichmay affect the outcome assessment.
15. Patients with mechanical heart valve. Biological valves are acceptable.
16. Patients with risk of embolism (including a history of left heart thrombus, mitralstenosis with atrial fibrillation, acute pericarditis or subacute bacterialendocarditis). Atrial fibrillation without mitral stenosis is acceptable.
17. Investigators believe co-morbidities would be detrimental to the patient when thestudy begins.
18. Patients difficult to follow up or with poor compliance due to various reasons (suchas geographical and social factors, drug or alcohol abuse, etc.)
19. Patient or his or her legal guardian/representative is unable or unwilling to give thewritten informed consent.
20. Patients is in a condition that is not suitable for "puncture aspiration + urokinase"treatment.