EUS-guided Celiac Plexus Neurolysis for the Treatment of Abdominal Pain in Pancreatic Cancer

Last updated: May 7, 2019
Sponsor: Changhai Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pancreatic Cancer

Colic

Digestive System Neoplasms

Treatment

N/A

Clinical Study ID

NCT03940027
CPN
  • Ages 18-75
  • All Genders

Study Summary

Studies have shown that injecting local anesthetics in areas rich in blood vessels increases the risk of drug injection into blood vessels by mistake and increases the systemic absorption of drugs, which may increase the incidence of central nervous system and cardiovascular system toxic events caused by local anesthetics.EUS-CPN-related complications have not been clearly associated with local anesthetic adverse events.However, EUS-CPN local anesthetic injection area is located around the beginning of the abdominal trunk with abundant large and small blood vessels. The choice of local anesthetics with higher safety than bupivacaine, such as ropivacaine, is of great significance to ensure the safety of eus-cpn, especially for eus-cpn beginners.At present, there are no reports on the application of ropivacaine in eus-cpn.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged between 18-75;

  2. Athologically confirmed as pancreatic cancer and clinically evaluated as advanced andunresectable;

  3. The visual analogue scale (VAS) for pain ≥ 4；

  4. Never received treatment for peritoneal plexus lesion or block；

  5. Voluntary signing of written informed consent

Exclusion

Exclusion Criteria:

  1. Women during pregnancy；

  2. Cannot or refuses to sign the informed consent；

  3. Blood clotting disorder（PLT <50 × 103/μL, INR > 1.5）；

  4. Celiac infection；

  5. Severe esophageal or gastric varices and ulcers which may affect operation;

  6. The anatomical variation of the abdominal trunk abdominal aorta and could not beaccurately located;

  7. Alcohol allergy

  8. Severe cardiopulmonary dysfunction and inability to tolerate the risk of intravenousanesthesia;

  9. History of mental illness;

  10. Patients with other chronic and acute diseases with unstable conditions that areexpected to affect the efficacy evaluation and completion of the study.

Study Design

Total Participants: 120
Study Start date:
February 10, 2019
Estimated Completion Date:
February 28, 2021

Connect with a study center

  • Changhai Hospital, Second Military Medical University

    Shanghai, 200433
    China

    Active - Recruiting

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