ECCO2R - Mechanical Power Study

Last updated: May 3, 2019
Sponsor: University of Milan
Overall Status: Active - Recruiting

Phase

N/A

Condition

Acute Respiratory Distress Syndrome (Ards)

Treatment

N/A

Clinical Study ID

NCT03939260
13175/2019
  • Ages > 18
  • All Genders

Study Summary

Although mechanical ventilation remains the cornerstone of ARDS treatment, several experimental and clinical studies have undoubtedly demonstrated that it can contribute to high mortality through the developing of ventilator induced lung injury even in patients with plateau pressure <30 cmH2O. Since now there are no studies exploring the application of low flow extracorporeal CO2 removal and ultraprotective ventilation to reduce mechanical power, a composite index of VILI, independently from the value of plateau pressure or the severity of hypercapnia.

Eligibility Criteria

Inclusion

Inclusion Criteria: ARDS patients undergoing mechanical ventilation with:

  • PaO2/FiO2 <150 with a level of positive end expiratory pressure (PEEP) of 10 cmH2O orhigher with a FiO2 > 0.5

  • Plateau pressure of 28 cmH2O or higher with tidal volume of 6 ml/Kg of ideal bodyweight

  • Mechanical power of 18 J/min or higher.

Exclusion

Exclusion Criteria:

  • <18 years of age

  • Pregnancy

  • Obesity with BMI> 30

  • Platelets <30 G/l

  • Decompensated heart failure or acute coronary syndrome

  • Acute brain injury

  • Contraindication for systemic anticoagulation (for example, gastrointestinal bleeding,recent cerebrovascular accident, or chronic bleeding disorder, recent major surgery)

  • Patient moribund, decision to limit therapeutic interventions

  • Catheter access to femoral vein or jugular vein impossible

  • Pneumothorax.

Study Design

Total Participants: 15
Study Start date:
March 20, 2019
Estimated Completion Date:
March 31, 2024

Connect with a study center

  • ASST-Santi Paolo e Carlo, San Paolo Hospital

    Milan, 20142
    Italy

    Active - Recruiting

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