Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection (PUNCH CD3-OLS)

Inclusion Criteria:

1. ≥ 18 years old.

2. Medical record documentation of either: a) a current diagnosis or history ofrecurrent CDI as determined by the treating physician, b) or has had at least twoepisodes of severe CDI resulting in hospitalization.

3. Is currently taking or was just prescribed antibiotics to control CDI relateddiarrhea at the time of enrollment. [Note: Subject's CDI diarrhea must be controlled (<3 unformed/loose stools/day) while taking antibiotics during screening.]

Exclusion Criteria:

1. Has continued CDI diarrhea despite being on a course of antibiotics prescribed forCDI treatment.

2. Requires systemic antibiotic therapy for a condition other than CDI.

3. Fecal microbiota transplant (FMT) within the past 6 months.

4. FMT with an associated serious adverse event related to the FMT product orprocedure.

5. Bezlotoxumab (CDI monoclonal antibodies) if received within the last year.

6. CD4 count <200/mm^3 during Screening.

7. An absolute neutrophil count of <1000 cells/µL during Screening.

8. Pregnant, breastfeeding, or intends to become pregnant during study participation.