Discovering New Genetic Markers in Adults and Children Who May Be At Risk for Hereditary Forms of Cancer

Inclusion Criteria:

• Individuals who have undergone clinical and/or research genetic evaluation, found tohave or not have a germline genetic variant (pathogenic, likely pathogenic, variantof uncertain/unknown significance, likely benign).

• Individuals with or without a personal history of malignant or pre-malignant lesionswho demonstrate: a) clinical findings suggestive of a genetic cancer susceptibilitysyndrome including very early age at onset, multiple primary malignancies, or otherfeatures; and/or b) family histories suggestive of a genetic cancer susceptibilitysyndrome, or c) other features suggesting inherited etiology of malignancy asdetermined by the PI.

• Family members of the above participants. Both children (with parental consent asage appropriate) and adults are eligible to participation.

• Individuals may or may not be enrolled MSK patients; probands may be referred to (orself-referred to) the study and may be enrolled at discretion of the PI and if ableto provide informed consent.

• Biospecimens derived from deceased family members may be used for research in thisstudy if consent if provided by the executor of the estate of that individual.

Exclusion Criteria:

• Patients will be excluded from this study if he/she has physical, cognitive orpsychiatric conditions that interfere with ability to give meaningful informedconsent.