Safety and Immunogenicity of V114 in Children Infected With Human Immunodeficiency Virus (HIV) (V114-030/PNEU-WAY PED)

Inclusion Criteria:

• Male or female between the ages of 6 and 17 years (inclusive) infected with HIV andhas a Cluster of Differentiation 4+ (CD4+) T-cell count ≥200 cells/µL and plasma HIVribonucleic acid (RNA) <50,000 copies/mL
• Is Pneumococcal Conjugate Vaccine (PCV) naïve, previously vaccinated with a <13-valentPCV, partially vaccinated with Prevnar 13™, or has a history of previous Prevnar 13™vaccination ≥3 years before Visit 2 (Day 1)
• Is PnPs vaccine naïve or has a history of 1 previous PnPs vaccination ≥5 years beforeVisit 2 (Day 1)
• Female participant: not pregnant, not breastfeeding and 1) not of childbearingpotential, or 2) of childbearing potential and agrees to practice contraceptionthrough 6 weeks after administration of last dose of the study vaccine.

Exclusion Criteria:

• History of World Health Organization (WHO) HIV classification of clinical Stage 4disease within the past 12 months
• History of invasive pneumococcal disease
• Known hypersensitivity to any vaccine component
• Known or suspected congenital immunodeficiency (other than HIV infection), functionalor anatomic asplenia, or history of autoimmune disease
• Bleeding disorder contraindicating intramuscular vaccinations
• History of malignancy ≤5 years prior to signing informed consent/assent, except foradequately treated basal cell or squamous cell skin cancer or in situ cervical cancer
• Female participant: positive urine or serum pregnancy test
• Expect to receive any pneumococcal vaccine during the study outside of the protocol
• Receiving immunosuppressive therapy, including chemotherapeutic agents used to treatcancer or other conditions, and interventions associated with organ or bone marrowtransplantation, or autoimmune disease
• Received a blood transfusion or blood products within 6 months of enrollment
• Participated in another clinical study of an investigational product within 2 monthsof enrollment
• Current user of recreational or illicit drugs or history of drug or alcohol abuse ordependence