The Pathogenesis of Human Senile Cataract

Last updated: April 6, 2019
Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vision Loss

Eye Disease

Eye Disorders/infections

Treatment

N/A

Clinical Study ID

NCT03907358
Shanghai1st-cataract-001
  • Ages 5-94
  • All Genders

Study Summary

To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with the explicit diagnosis of cataract (including senile cataract,congenital cataract, complicated cataract, metabolic cataract, traumatic cataract,etc.) in the operated eye are willing to undergo cataract surgery.

Exclusion

Exclusion Criteria:

  • Patients whose cataracts need not be operated

  • Patients with any contraindications to cataract surgery

  • Patients are unwilling to undergo cataract surgery

Study Design

Total Participants: 20
Study Start date:
December 07, 2016
Estimated Completion Date:
June 30, 2020

Study Description

Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Connect with a study center

  • Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University

    Shanghai, 200080
    China

    Active - Recruiting

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