Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery

Inclusion Criteria - To be considered eligible for participation in this study, a participant must satisfy each of the following criteria:

1. Age ≥ 18 years

2. Scheduled to undergo coronary artery bypass graft (CABG) surgery (with or withoutcardiopulmonary bypass (CPB); with or without single valve repair/replacement)

3. CABG procedure included/planned to include at least two saphenous vein grafts

4. CABG procedure occurred within the past 21 days, or is planned within the next 60days

5. On a moderate to high intensity statin therapy (defined as atorvastatin 40-80mgdaily, rosuvastatin 20-40mg or simvastatin 40mg daily) unless a lower dose, oranother statin or non-statin therapy is clinically justified

Exclusion Criteria - A participant will be ineligible for participation in this study if he or she satisfies any one or more of the following criteria:

1. Patients in whom additional lowering of LDL-C with evolocumab is deemed to beclinically inappropriate

2. Allergy to contrast dye

3. Known severe hepatic impairment (Childs-Pugh, Class C).

4. Known renal disease with estimated glomerular filtration rate (eGFR) < 30mL/min/1.73m2

5. Recipient of any major organ transplant (eg, lung, liver, heart, bone marrow)

6. Use of cholesterylester transfer protein (CETP) inhibition treatment within 12months prior to randomization.

7. Current, prior within past year, or known planned use of PCSK9 inhibition treatment

8. Severe cardiovascular or concomitant non-cardiovascular disease that is expected toreduce life expectancy to less than 2 years

9. Major active infection, or major hematologic, renal, respiratory, metabolic,gastrointestinal or endocrine dysfunction

10. Women who are pregnant or breastfeeding

11. Women of child bearing potential who are unwilling to use proper family planning orbirth control methods to avoid pregnancy. Women are considered post-menopausal andnot of childbearing potential after 12 months of natural (spontaneous) amenorrhea orhave had a surgical procedure such as hysterectomy which makes pregnancy impossible.

12. Known intolerance or allergy to evolocumab or other PCSK9 inhibitors.

13. Currently taking simvastatin >40mg/day, niacin or bile acid sequestrants

14. Known latex allergy

15. Inability to comply with protocol-required study visits or procedures, includingadministration of study drug

16. Known history of cancer within the past 5 years (except for carcinoma in-situ of thecervix, stage 1 prostate cancer or adequately treated non-melanoma carcinomas of theskin)

17. Participation in another investigational device or drug study which is likely toaffect the primary outcome, within 30 days of planned initiation of study drug

18. NYHA class IV

19. Pacemaker or other implantable device implanted within 30 days prior to screening

Additional postoperative exclusion criteria:

1. Received only <2 vein grafts

2. Major peri-operative complications following CABG surgery (e.g. stroke, MI, renalfailure requiring dialysis, or postoperative ICU stay > 5 days) prior torandomization