Protocol of Diuretics Use in Congestive Therapy in Heart Failure

Last updated: January 27, 2026
Sponsor: University Hospital, Clermont-Ferrand
Overall Status: Completed

Phase

4

Condition

Chest Pain

Congestive Heart Failure

Heart Failure

Treatment

Hydrochlorothiazide

Furosemide

Clinical Study ID

NCT03892148
CHU-428
2018-A02971-54
  • Ages > 18
  • All Genders

Study Summary

The main objective of the study is to determine if a diuretic adaptation protocol in the decompensation of chronic heart failure is more effective but also safer than the current non-protocolized practice.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients hospitalized for chronic decompensated congestive heart failurewithout acute pulmonary edema and acute cardiac decompensation against a backgroundof hypertensive crisis

  • covered under a social security program

  • with legal capacity to give voluntary informed consent to participate in the study

Exclusion

Exclusion Criteria:

  • First episode of decompensated congestive heart failure

  • Protocolized shock or hypotension (<90 mmHg blood pressure) managed or requiringnitrovasodilators or non-invasive ventilation

  • One of the following cardiovascular pathologies: acute myocardial infarction /cardiac tamponade / aortic dissection / acute pulmonary embolism / heart transplant / ventricular assist device / acute pulmonary edema / hypertensive crisis

  • More than 12h of intravenous diuretics administered prior to inclusion

  • Generalized edema caused by cirrhosis or nephrotic syndrome

  • Requiring pleural or peritoneal tap for therapeutic purposes

  • Patient allergic or intolerant to furosemide and on long-term bumetanide use

  • Patient in dialysis or end-stage chronic kidney disease (CKD-EPI-calculated GFR <15mL/min/1.73m²) or acute kidney injury of known non-cardiac cause

  • Severe hypokalemia (< 3 mmol/L) on admission

  • Patient who is pregnant, breastfeeding, or of childbearing age not on effectivecontraception

  • Adult patient safeguarded under court protection measures (guardianship, wardship,or judicial protection)

Study Design

Total Participants: 299
Treatment Group(s): 2
Primary Treatment: Hydrochlorothiazide
Phase: 4
Study Start date:
May 17, 2019
Estimated Completion Date:
January 16, 2023

Study Description

Diuretics are the main treatment for congestive decompensation of chronic heart failure. For symptomatic purposes, the goal is to decrease the volume overload. In these patients, loop diuretics are used in high doses, sometimes in combination with other classes of diuretics such as thiazides to achieve synergistic, faster and more effective action, and to combat diuretic's resistance. This use, well known to cardiologists and based on a rich pharmacology, more than 40 years old, lacks robust scientific data in real life. Current studies are mainly based on patients with renal insufficiency or limited to cardio-renal syndrome. The CARRESS-H study in 2012 is one of them. The protocol for the use of diuretics from this study was included in 2017 as a benchmark in a publication of the NEJM. It therefore seems necessary to consider the exercise of this protocol in the management of the decompensation of chronic cardiac heart failure. There is, to the investigator's knowledge, no similar study to test this protocol as a "real life" exercise.

Connect with a study center

  • Ch Annecy

    Annecy,
    France

    Site Not Available

  • Ch Annecy

    Annecy 3037543,
    France

    Site Not Available

  • Chu Clermont-Ferrand

    Clermont-Ferrand, 63003
    France

    Site Not Available

  • Chu Clermont-Ferrand

    Clermont-Ferrand 3024635, 63003
    France

    Site Not Available

  • CHU de GRENOBLE

    Grenoble,
    France

    Site Not Available

  • CHU de GRENOBLE

    Grenoble 3014728,
    France

    Site Not Available

  • Ch Issoire

    Issoire,
    France

    Site Not Available

  • Ch Issoire

    Issoire 3012664,
    France

    Site Not Available

  • CH PUY

    Le Puy-en-Velay,
    France

    Site Not Available

  • CH PUY

    Le Puy-en-Velay 3002465,
    France

    Site Not Available

  • Ch Lyon Sud

    Lyon,
    France

    Active - Recruiting

  • Infirmerie Protestante de Lyon

    Lyon, 69300
    France

    Site Not Available

  • Ch Lyon Sud

    Lyon 2996944,
    France

    Site Not Available

  • Infirmerie Protestante de Lyon

    Lyon 2996944, 69300
    France

    Site Not Available

  • Ch Montlucon

    Montluçon,
    France

    Site Not Available

  • Ch Moulins

    Moulins,
    France

    Site Not Available

  • Ch Moulins

    Moulins 2991481,
    France

    Site Not Available

  • CH RIOM

    Riom,
    France

    Site Not Available

  • CH RIOM

    Riom 2983489,
    France

    Site Not Available

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.