Nab-paclitaxel and S-1 in Patients With Locally Advanced Pancreatic Cancer

Inclusion Criteria:

1. Patients have good compliance, can understand the research process of this study, andsign a written informed consent

2. Patients with pathologically confirmed pancreatic adenocarcinoma.

3. Patients who have not received prior chemotherapy, radiotherapy or other systematictreatment for pancreatic cancer;

4. Patients with locally advanced pancreatic cancer ( NCCN Version 1，2019 criteria).

5. ECOG PS 0-1;

6. Tumor size is measurable according to RECIST1.1 criteria

7. Expected survival over 3 months;

8. Bone marrow function: neutrophils≥1.5x109/L, platelets ≥100x109/L, hemoglobin≥ 90g/L;

9. Liver and kidney function: serum creatinine≤1.5ULT; AST and ALT≤ 2.5 ULT; totalbilirubin ≤ 1.5 ULT;

10. No contraindications to the use of S-1 and nab-paclitaxel.

Exclusion Criteria:

1. ≥ Grade 2 existing peripheral neuropathy;

2. Any other malignancy within 5 years prior to enrollment, with the exception ofadequately treated in-situ carcinoma of the cervix, uteri, bladder, or nonmelanomatousskin cancer.

3. Active, uncontrolled infection(s) requiring systemic therapy, defined as ongoingsigns/symptoms related to the infection without improvement despite appropriatetreatment.

4. Severe, active co-morbidity, defined as follows: Unstable angina and/or congestive heart failure requiring hospitalization within thelast 6 months Transmural myocardial infarction within the 6 months of studyregistration Uncontrolled hypertension, diabetes or arrhythmia. Chronic obstructivepulmonary disease exacerbation or other respiratory illness requiring hospitalization.

5. Not able to take medicine orally.

6. Pregnancy or lactation, and women of childbearing age who refused to take appropriatecontraceptive measures during the course of this study;

7. Participation in other clinical trial within 30 days before the first dose of thedrug;