Insulin Regulation of Lipolysis and Lipolysis Proteins

Last updated: January 26, 2026
Sponsor: Mayo Clinic
Overall Status: Active - Recruiting

Phase

1

Condition

Obesity

Diabetes Prevention

Treatment

Placebo

Deferred weight loss

Immediate weight loss

Clinical Study ID

NCT03866408
17-009837
2R01DK040484-30
  • Ages 18-55
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Men and Women between the ages of 18 and 55.

  • Women will be premenopausal

  • Non obese adults BMI between 18-25

  • Obese BMI 30-38

Exclusion Criteria, Pioglitazone package insert of contraindications for use:

  • Initiation in patients with established New York Heart Associations (NYHA) class III or IV Heart failure.

  • Use in patients with known hypersensitivity to pioglitazone or any other component of ACTOSE.

Study Design

Total Participants: 64
Treatment Group(s): 4
Primary Treatment: Placebo
Phase: 1
Study Start date:
November 12, 2018
Estimated Completion Date:
December 31, 2026

Study Description

  1. The investigators will determine whether impaired insulin-induced suppression of lipolysis (as measured by IC50) is related to the above mentioned lipolysis proteins in groups of volunteers known to vary widely with regards to abdominal adipocyte size and regulation of adipose tissue lipolysis.

  2. The investigators will determine whether the improved insulin regulation of lipolysis resulting from treatment with the PPARγ agonist pioglitazone, with or without weight loss, can be linked to specific changes in sets of PPARγ-responsive adipocyte lipolysis proteins in UBO adults.

Connect with a study center

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic in Rochester

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

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