Evaluation of the Duration of Effect of Bimatoprost SR in Participants With Open-Angle Glaucoma or Ocular Hypertension

Last updated: February 9, 2024
Sponsor: AbbVie
Overall Status: Active - Not Recruiting

Phase

3

Condition

Ocular Hypertension

Vascular Diseases

Stress

Treatment

Bimatoprost (SR)

Clinical Study ID

NCT03850782
1698-301-007
2018-002574-52
2022-502380-37-00
  • Ages > 18
  • All Genders

Study Summary

This study evaluates the duration of intraocular pressure (IOP)-lowering effect and safety of as needed administrations of Bimatoprost sustained release (SR) in participants with open-angle glaucoma (OAG) or ocular hypertension (OHT) who are not adequately managed with topical IOP-lowering medication for reasons other than medication efficacy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of either open angle glaucoma (OAG) (i.e., primary OAG, pseudoexfoliationglaucoma, pigmentary glaucoma) or ocular hypertension requiring intraocularpressure-lowering treatment.

Exclusion

Exclusion Criteria:

  • Concurrent or anticipated enrollment in another investigational drug or device studyor participation in such a study within 2 months prior to enrolling in this study.
  • Previous administration with Bimatoprost SR in the study eye.

Study Design

Total Participants: 515
Treatment Group(s): 1
Primary Treatment: Bimatoprost (SR)
Phase: 3
Study Start date:
February 28, 2019
Estimated Completion Date:
August 09, 2025

Connect with a study center

  • Consultorio Oftalmologico Dr. Fabian Lerner /ID# 235855

    Caba, Buenos Aires 1122
    Argentina

    Site Not Available

  • Hospital Universitario Austral /ID# 237727

    Pilar, Buenos Aires 1629
    Argentina

    Site Not Available

  • Oftalmología Global /ID# 239187

    Rosario, Santa Fe 2000
    Argentina

    Site Not Available

  • Hospital Italiano /ID# 235851

    Buenos Aires, 1181
    Argentina

    Site Not Available

  • Centro Privado de Ojos /ID# 241283

    Ciudad Autonoma Buenos Aires, 1033
    Argentina

    Site Not Available

  • Centro oftalmologico Dr Charles /ID# 235881

    Ciudad de Buenos Aires, 1116
    Argentina

    Site Not Available

  • Oftar Mendoza /ID# 240535

    Mendoza, 1019
    Argentina

    Site Not Available

  • Queensland Eye Institute /ID# 238466

    South Brisbane, Queensland 4101
    Australia

    Site Not Available

  • Eye Surgery Associates /ID# 235873

    East Melbourne, Victoria 3002
    Australia

    Site Not Available

  • Multiprofile Hospital for Active Treatment "Lozenetz" /ID# 244053

    Sofiya, Sofia 1407
    Bulgaria

    Site Not Available

  • Medical Center Oxycom Burgas /ID# 235580

    Burgas, 8008
    Bulgaria

    Site Not Available

  • UMHAT Sveti Georgi /ID# 237027

    Plovdiv, 4002
    Bulgaria

    Site Not Available

  • MHAT Hadzhi Dimitar /ID# 238248

    Sliven, 8800
    Bulgaria

    Site Not Available

  • MHAT Dr. Bratan Shukerov /ID# 235498

    Smolyan, 4700
    Bulgaria

    Site Not Available

  • Diagnostic consultative center Aleksandrovska /ID# 238105

    Sofia, 1431
    Bulgaria

    Site Not Available

  • Medical center for eye healt Focus Ltd /ID# 235575

    Sofia, 1303
    Bulgaria

    Site Not Available

  • Pentagram Eye Hospital /Id# 235813

    Sofia, 1309
    Bulgaria

    Site Not Available

  • Specialized Hospital for Active Treatment in Ocular Diseases "Zrenie" /ID# 235500

    Sofia, 1408
    Bulgaria

    Site Not Available

  • St. Sofia Hospital /ID# 235525

    Sofia, 1618
    Bulgaria

    Site Not Available

  • MHAT Trakia /ID# 238137

    Stara Zagora, 6004
    Bulgaria

    Site Not Available

  • Medical Center -Verea /ID# 235494

    Stara Zagora, 6000
    Bulgaria

    Site Not Available

  • Medical center Orfey /ID# 237344

    Stara Zagora, 6000
    Bulgaria

    Site Not Available

  • Specialized Ophthalmological Hospital for Active Treatment - Varna /ID# 235962

    Varna, 9002
    Bulgaria

    Site Not Available

  • FN Hradec Kralove

    Hradec Kralove, 50005
    Czechia

    Site Not Available

  • Ocni klinika Pardubice /ID# 235944

    Pardubice, 530 02
    Czechia

    Site Not Available

  • VFN

    Prague, 12808
    Czechia

    Site Not Available

  • Fakultni nemocnice Kralovske Vinohrady /ID# 234323

    Praha, 100 34
    Czechia

    Site Not Available

  • Vseobecna fakultni nemocnice v Praze /ID# 234422

    Praha, 128 08
    Czechia

    Site Not Available

  • Rigshospitalet Glostrup /ID# 235743

    Glostrup, Hovedstaden 2600
    Denmark

    Site Not Available

  • CHU de Bordeaux Hopital Pellegrin

    Bordeaux, Gironde 33076
    France

    Site Not Available

  • CHU Angers

    Angers, 49933
    France

    Site Not Available

  • Ophthalmologie, Polyclinique de la Baie

    Avranches, 50300
    France

    Site Not Available

  • Clinique Honore Cave

    Montauban, 82017
    France

    Site Not Available

  • Universitatsklinikum Freiburg /ID# 238048

    Freiburg im Breisgau, Baden-Wuerttemberg 79106
    Germany

    Site Not Available

  • Universitaetsklinikum Freiburg, Klinik fuer Augenheilkunde

    Freiburg, Baden-Württemberg 79106
    Germany

    Site Not Available

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 237069

    Kiel, Schleswig-Holstein 24105
    Germany

    Site Not Available

  • Klinikum Dresden Friedrichstadt /ID# 235308

    Dresden, 01067
    Germany

    Site Not Available

  • Universitaetsmedizin Goettingen /ID# 237377

    Goettingen, 37075
    Germany

    Site Not Available

  • Asklepios Kinik Nord - Heidberg Augenklinik /ID# 235955

    Hamburg, 22417
    Germany

    Site Not Available

  • St. Franziskus-Hospital /ID# 237714

    Muenster, 48145
    Germany

    Site Not Available

  • Franziskus Hospital Muenster

    Munster, 48145
    Germany

    Site Not Available

  • Dietrich-Bonhoeffer-Klinikum /ID# 235262

    Neubrandenburg, 17036
    Germany

    Site Not Available

  • Universitaetsmedizin Rostock /ID# 237263

    Rostock, 18057
    Germany

    Site Not Available

  • Augenzentrum Dr Hamacher /ID# 235537

    Starnberg, 82319
    Germany

    Site Not Available

  • Bugat Pal Hospital

    Gyongyos, Heves 3200
    Hungary

    Site Not Available

  • Bugat Pal Korhaz /ID# 238144

    Gyongyos, Heves 3200
    Hungary

    Site Not Available

  • Gyongyosi Bugat Pal Korhaz /ID# 238144

    Gyongyos, Heves 3200
    Hungary

    Site Not Available

  • Bugat Pal Korhaz /ID# 238144

    Gyöngyös, Heves 3200
    Hungary

    Site Not Available

  • Markusovszky Egyetemi Oktatokorhaz /ID# 237383

    Szombathely, Vas 9700
    Hungary

    Site Not Available

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 237383

    Szombathely, Vas 9700
    Hungary

    Site Not Available

  • Budapest Retina Intezet /ID# 235950

    Budapest, 1133
    Hungary

    Site Not Available

  • Jahn Ferenc Del-pesti Korhaz es Rendelointezet /ID# 237111

    Budapest, 1204
    Hungary

    Site Not Available

  • Royal Victoria Eye and Ear Hospital /ID# 235546

    Dublin, 2
    Ireland

    Site Not Available

  • Institute of Eye Surgery /ID# 235547

    Waterford, X91 DH9W
    Ireland

    Site Not Available

  • University of Catanzaro /ID# 238066

    Catanzaro, Calabria 88100
    Italy

    Site Not Available

  • Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 235571

    Bari, 70124
    Italy

    Site Not Available

  • Eye Clinic University of Catania /ID# 235573

    Catania, 95123
    Italy

    Site Not Available

  • Ospedale Ss. Annunziata /ID# 236587

    Chieti, 66100
    Italy

    Site Not Available

  • Fondazione IRCCS Policlinico /ID# 236909

    Pavia, 27100
    Italy

    Site Not Available

  • University of Perugia /ID# 235811

    Perugia, 06156
    Italy

    Site Not Available

  • Ospedale Fiorini di Terracina

    Roma, 1850
    Italy

    Site Not Available

  • Fondazione Bietti - Ospedale Britannico /ID# 235495

    Rome, 00184
    Italy

    Site Not Available

  • Sapienza University of Rome - Polo Pontino /ID# 237451

    Terracina, 04019
    Italy

    Site Not Available

  • Southern Eye Specialists /ID# 236080

    Christchurch, Canterbury 8013
    New Zealand

    Site Not Available

  • Capital Eye Specialists /ID# 236112

    Wellington, 6011
    New Zealand

    Site Not Available

  • Wojskowy Instytut Medyczny /ID# 237031

    Warsaw, Mazowieckie 04-349
    Poland

    Site Not Available

  • Optimum Profesorskie Centrum Okulistyki Sp. z o.o. /ID# 237076

    Gdansk, Pomorskie 80-809
    Poland

    Site Not Available

  • Optinum Profesorskie Centrum Okulistyki /ID# 237076

    Gdansk, Pomorskie 80-809
    Poland

    Site Not Available

  • Profesorskie Centrum Okulistyki

    Gdańsk, 80-809
    Poland

    Site Not Available

  • Gabinet Okulistyczny Edward Wylegala /ID# 235946

    Katowice, 40-594
    Poland

    Site Not Available

  • Medical Center Julianow /ID# 235961

    Lodz, 91-485
    Poland

    Site Not Available

  • Centrum Diagnostyki i Mikrochirurgii Oka - LENS sp. z o.o /ID# 235928

    Olsztyn, 10-424
    Poland

    Site Not Available

  • S. Fyodorov Eye Microsurgery Federal State Institution /ID# 235984

    Novosibirsk, 630071
    Russian Federation

    Site Not Available

  • Clinical ophthalmology hospital n.a. V.P. Vihodtsev. /ID# 236042

    Omsk, 644024
    Russian Federation

    Site Not Available

  • Pretoria Eye Institute - Private Practice /ID# 235658

    Pretoria, Gauteng 0083
    South Africa

    Site Not Available

  • Somerset Eye Specialist Medical & Surgical Centre /ID# 235540

    Somerset West, Western Cape 7130
    South Africa

    Site Not Available

  • Somerset Eye Specialist Medical & Surgical Centre

    Cape Town, 7130
    South Africa

    Site Not Available

  • Dr Lynette Venter

    Westdene, 9301
    South Africa

    Site Not Available

  • Norrlands University hospital /ID# 237553

    Umea, Vasterbottens Lan 581 85
    Sweden

    Site Not Available

  • Hinchingbrooke Hospital

    Huntingdon, Cambridgeshire PE29 6NT
    United Kingdom

    Site Not Available

  • The Princess Alexandra NHS Trust /ID# 234433

    Harlow, Essex CM20 1QX
    United Kingdom

    Site Not Available

  • Oxford University Hospitals NHS Foundation Trust /ID# 237282

    Oxford, Oxfordshire OX3 9DU
    United Kingdom

    Site Not Available

  • Epsom /ID# 235931

    Epsom, Surrey KT18 7EG
    United Kingdom

    Site Not Available

  • Birmingham & Midland Eye Center /ID# 235067

    Birmingham, B18 7QH
    United Kingdom

    Site Not Available

  • Cambridge University Hospitals NHS Foundation Trust /ID# 238255

    Cambridge, CB2 0QQ
    United Kingdom

    Site Not Available

  • Mid Essex Hospitals NHS Trust /ID# 237776

    Chelmsford, CM1 7ET
    United Kingdom

    Site Not Available

  • East Suffolk and North Essex NHS Foundation Trust /ID# 234657

    Colchester, CO4 5JL
    United Kingdom

    Site Not Available

  • Mid-Cheshire Hospitals NHS Trust /ID# 235418

    Crewe, CW1 4QJ
    United Kingdom

    Site Not Available

  • Liverpool University Hospitals NHS Foundation Trust /ID# 237095

    Liverpool, L7 8XP
    United Kingdom

    Site Not Available

  • Liverpool University Hospitals NHS Foundation Trust /ID# 237321

    Liverpool, L7 8XP
    United Kingdom

    Site Not Available

  • Central Middlesex Hospital /ID# 236216

    London, NW10 7NS
    United Kingdom

    Site Not Available

  • King's College Hospital NHS Foundation Trust /ID# 237275

    London, SE5 9RS
    United Kingdom

    Site Not Available

  • Norfolk and Norwich University Hospitals NHS Foundation Trust

    Norwich, NR1 3SR
    United Kingdom

    Site Not Available

  • Peterborough City Hospital

    Peterborough, PE3 9GZ
    United Kingdom

    Site Not Available

  • York and Scarborough Teaching Hospitals NHS Foundation Trust /ID# 237683

    York, YO31 8HE
    United Kingdom

    Site Not Available

  • Horizon Eye Specialists & Lasik Centers /ID# 235240

    Sun City, Arizona 85351
    United States

    Site Not Available

  • Atlantis Eye Care /ID# 235530

    Huntington Beach, California 92647
    United States

    Site Not Available

  • Lakeside Vision Center /ID# 234970

    Irvine, California 92604
    United States

    Site Not Available

  • Global Research Foundation /ID# 237350

    Los Angeles, California 90041-1718
    United States

    Site Not Available

  • Tayani Institute / American Institute of Research

    Mission Viejo, California 92691
    United States

    Site Not Available

  • The Eye Research Foundation /ID# 234521

    Newport Beach, California 92663-3637
    United States

    Site Not Available

  • Byers Eye Institute Stanford /ID# 235544

    Palo Alto, California 94303
    United States

    Site Not Available

  • Foothill Eye Institute /ID# 235640

    Pasadena, California 91107
    United States

    Site Not Available

  • Martel Eye Medical Group

    Rancho Cordova, California 95670
    United States

    Site Not Available

  • Connecticut Eye Consultants P.C. /ID# 234981

    Danbury, Connecticut 06810
    United States

    Site Not Available

  • Specialty Retina Center /ID# 236045

    Coral Springs, Florida 33067
    United States

    Site Not Available

  • Segal Drug Trials, Inc /ID# 235784

    Delray Beach, Florida 33484
    United States

    Site Not Available

  • International Research Center /ID# 238050

    Tampa, Florida 33603
    United States

    Site Not Available

  • Specialty Retina Center

    Weston, Florida 33326
    United States

    Site Not Available

  • Thomas Eye Group PC /ID# 235737

    Sandy Springs, Georgia 30328
    United States

    Site Not Available

  • Indiana University - Glick Eye Institute /ID# 235886

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Midwest Eye Institute /ID# 237876

    Indianapolis, Indiana 46290
    United States

    Site Not Available

  • Tulane University /ID# 237632

    New Orleans, Louisiana 70112-2699
    United States

    Site Not Available

  • Ophthalmic Consultants of Boston /ID# 236534

    Boston, Massachusetts 02129
    United States

    Site Not Available

  • Clinical Eye Research of Boston LLC /ID# 234966

    Winchester, Massachusetts 01890
    United States

    Site Not Available

  • University of Michigan, Kellogg Eye Center /ID# 236496

    Ann Arbor, Michigan 48105
    United States

    Site Not Available

  • Fraser Eye Center /ID# 235790

    Fraser, Michigan 48026
    United States

    Site Not Available

  • Moyes Eye Center PC /ID# 234989

    Kansas City, Missouri 64154
    United States

    Site Not Available

  • Silverstein Eye Centers /ID# 237881

    Kansas City, Missouri 64034
    United States

    Site Not Available

  • Clinical Research Center of Nevada LLC

    Las Vegas, Nevada 89117
    United States

    Site Not Available

  • Alterman Modi & Wolter /ID# 235248

    Poughkeepsie, New York 12603-2455
    United States

    Site Not Available

  • The Ohio State University /ID# 236790

    Columbus, Ohio 43210-1257
    United States

    Site Not Available

  • AMA Eyes Research Institute /ID# 235542

    Marysville, Ohio 43040
    United States

    Site Not Available

  • Dean McGee Eye Institute /ID# 236823

    Oklahoma City, Oklahoma 73104
    United States

    Site Not Available

  • Oklahoma Eye Surgeons /ID# 235849

    Oklahoma City, Oklahoma 73112
    United States

    Site Not Available

  • Drs Fine Hoffman & Sims LLC /ID# 235918

    Eugene, Oregon 97401
    United States

    Site Not Available

  • Ophthalmic Partners, PC /ID# 235741

    Bala-Cynwyd, Pennsylvania 19004
    United States

    Site Not Available

  • Scott and Christie and Associates /ID# 234593

    Cranberry Township, Pennsylvania 16066
    United States

    Site Not Available

  • Black Hills Regional Eye Institute /ID# 235075

    Rapid City, South Dakota 57701
    United States

    Site Not Available

  • Vance Thompson Vision /ID# 235072

    Sioux Falls, South Dakota 57108
    United States

    Site Not Available

  • Eye Specialty Group /ID# 235721

    Memphis, Tennessee 38120
    United States

    Site Not Available

  • Vanderbilt University Medical Center /ID# 237177

    Nashville, Tennessee 37232-0011
    United States

    Site Not Available

  • Advancing Vision Research /ID# 236681

    Smyrna, Tennessee 37167
    United States

    Site Not Available

  • ATX Clinical Trials Inc. dba Keystone Research /ID# 235868

    Austin, Texas 78731
    United States

    Site Not Available

  • Medical Center Ophthalmology Associates - Keystone Research /ID# 235787

    San Antonio, Texas 78240
    United States

    Site Not Available

  • Southern Utah Medical Research /ID# 235602

    Saint George, Utah 84790
    United States

    Site Not Available

  • Piedmont Eye Center /ID# 234534

    Lynchburg, Virginia 24502
    United States

    Site Not Available

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