Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis

Last updated: February 10, 2019
Sponsor: National Taiwan University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sjogren's Syndrome

Pemphigus Vulgaris (Pv)

Urticaria

Treatment

N/A

Clinical Study ID

NCT03839069
201503027DINB
  • Ages 20-85
  • All Genders

Study Summary

This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age 20-85 years old

  • unilateral or bilateral cicatrizing conjunctivitis

  • severe aqueous deficiency dry eye ( Schirmer I test result of less than 2mm)

  • chronic ocular surface disease score (COCS) over 3 points

  • Oxford scheme over grade III

Exclusion

Exclusion Criteria:

  • active ocular infection

  • active corneal melting

  • severe xerostomia (modified Schirmer I test result of less than 25mm)

Study Design

Total Participants: 30
Study Start date:
September 01, 2016
Estimated Completion Date:
June 30, 2021

Study Description

Cicatrizing conjunctivitis can be the common presentation of many ocular surface diseases as Stevens-Johnson syndrome (SJS), mucous membrane pemphigoid (MMP), chemical burn, Sjogren syndrome, chronic graft-versus-host disease (GVHD) and ocular trauma. Ocular dryness in combination with symblepharon and corneal opacity in these patients could lead to the poor visual and life quality, and less favorable prognosis of ocular reconstruction.

This study aims to prospectively evaluate the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis. The investigators evaluate the saliva-tear productivity (functional outcome) and the survival of graft (anatomical outcome) every three months. The investigators would also validate whether minor salivary gland transplantation is beneficial for the participant prior to further ocular reconstruction as limbal transplantation and corneal grafting.

Connect with a study center

  • Department of Ophthalmology, National Taiwan University Hospital

    Taipei, 10002
    Taiwan

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.