Comparison Between Uterine Artery Doppler and Placental Vascular Indices in Prediction of Preeclampsia

Last updated: August 11, 2021
Sponsor: National Research Centre, Egypt
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pregnancy Complications

Treatment

N/A

Clinical Study ID

NCT03838887
placental vascular indices
  • Ages 18-35
  • Female
  • Accepts Healthy Volunteers

Study Summary

• Preeclampsia is a multisystem disorder that can cause considerable maternal and fetal morbidity and mortality. Late preeclampsia (with delivery >34 weeks) is more frequent and less serious than early preeclampsia (with delivery <34 weeks). Poor early placentation has been especially associated with early disease. Early identification of women at risk of preeclampsia is currently a crucial aim of antenatal care since they may benefit from prophylactic treatment and increased surveillance.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • A. Control group: Pregnant women:
  1. Age between 18-35 years
  2. Parity: primigravidas and multiparas.
  3. Have no history of preeclampsia or eclampsia.
  4. Have no history of chronic hypertension.
  5. Not diabetic.
  6. Not have antiphospholipid syndrome.
  7. Not have autoimmune disease such as SLE. B. High risk group: Pregnant women with:
  8. History of preeclampsia -Eclapmsia
  9. Chronic hypertension
  10. Diabetic
  11. Antiphospholipid syndrome.
  12. Autoimmune syndrome such as SLE.

Exclusion

Exclusion Criteria:

  • • Smoking
  • Dichorionic placentae
  • Fetal anomaly
  • Uterine fibroid at the site of placental implantation
  • Subchorionic hematoma

Study Design

Total Participants: 100
Study Start date:
June 01, 2021
Estimated Completion Date:
January 01, 2022

Study Description

  • The introduction of three-dimensional (3D) ultrasound techniques, with the option of calculating placental volume and measuring vascular indices, has created an excellent opportunity to study early changes in the uteroplacental circulation space, which includes the maternal spiral arteries and the intervillous space. This technology may allow a more direct evaluation of the abnormal placentation process thought to herald the development of preeclampsia.

  • The aim of this study was to assess the usefulness of placental volume and 3D vascular indices as reliable predictors of early preeclampsia in comparison to uterine artery Doppler

Connect with a study center

  • National Research Centre

    Cairo, 1234
    Egypt

    Active - Recruiting

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