Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop

Inclusion Criteria:

• COPD or suspected COPD ( Age>40, active or smoking history > 10pack/years), -

• Acute exacerbation (increasing dyspnea recently)

• One or more of the following criteria: increased sputum, modification of sputumpurulence,increased dyspnea,

• Moderate oxygen therapy: Oxygen flow < 8 lpm (or FiO2 < 0.60) to maintain a SpO2 >or = 92% (for long term oxygen therapy, the oxygen flow must be greater than baselineflow to maintain SpO2 > or = 92%)

Exclusion Criteria:

• Patient refusal

• COPD exacerbation with diagnosis highly related to pulmonary embolism, cardiacpulmonary edema, pneumothorax or sedative overdose

• No SpO2 signal

• Encephalopathy score > 2

• Delirium

• Other respiratory support needed (intubation or NIV)

• Patient on withdrawal life support

• Advance neoplasia (palliative stage) or terminal respiratory distress

• Unavailability of FreeO2 device at the randomisation

• Non optimal patient collaboration