Allogenic Cord Blood Transfusion in Patients With Cerebral Palsy

Last updated: January 17, 2023
Sponsor: State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Overall Status: Active - Recruiting

Phase

2

Condition

Cerebral Palsy

Treatment

N/A

Clinical Study ID

NCT03826498
12102017
  • Ages 1-10
  • All Genders

Study Summary

Cerebral palsy is a disorder of movement and posture resulted from a non-progressive lesion or injury of the immature brain. It is a leading cause of childhood onset disability.

Many experimental animal studies have revealed that umbilical cord blood is useful to repair neurological injury in brain.

On the basis of many experimental studies, umbilical cord blood is suggested as a potential therapy for cerebral palsy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Confirmed diagnosis: Cerebral Palsy.

Exclusion

Exclusion Criteria:

  • the presence of the following diseases in history: heart failure in the stage ofdecompensation, stroke in history less than 1 year ago, blood diseases;
  • decompensation of chronic and endocrinological diseases;
  • acute respiratory viral and bacterial infections, period less than 1 month after theacute phase.
  • HIV infection, hepatitis B and C.
  • oncological diseases, chemotherapy in the anamnesis;
  • tuberculosis.

Study Design

Total Participants: 40
Study Start date:
January 12, 2018
Estimated Completion Date:
December 26, 2024

Study Description

Cerebral palsy (CP) is a group of neurodevelopmental conditions with abnormal movement and posture resulted from a non-progressive cerebral disturbance. It is the most common cause of motor disability in childhood. Most therapies are palliative rather than restorative. Umbilical cord blood (UCB) may be used as restorative approach for children with CP.

Many experimental animal studies have revealed that UCB is beneficial to improve and repair neurological injuries, this effect achieved due to immune regulation and angiogenesis as well as the neuroprotective effect.

Based on animal studies and some clinical trials, UCB is suggested as a potential therapy for children with CP.

This study is prospective, non randomized (open label) with control group.

Connect with a study center

  • Medical Centre Dinasty

    Samara, 443095
    Russian Federation

    Active - Recruiting

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