Oocyte Freezing for Fertility Preservation in Benign Ovarian Tumors

Last updated: December 13, 2022
Sponsor: University Hospital, Lille
Overall Status: Active - Recruiting

Phase

N/A

Condition

Endometriosis

Ovarian Cysts

Treatment

N/A

Clinical Study ID

NCT03823833
2018_48
  • Ages 18-35
  • Female

Study Summary

Benign ovarian cysts are frequent during women's life. They are diagnosed with pelvic pain or fortuitously during an ultra-sonographic exam. In case of persistence,a surgery will be necessary to identify the nature of the cyst and assess its benignity. In some case, cysts are recurrent and multiple surgeries are needed leading to a significant risk of ovarian damage by follicular depletion. Oocyte cryopreservation is no longer considered as an experimental technique of Fertility Preservation since 2013 as it has been recognized to be efficient and safe. According to reproductive medicine scientific committees and the French ethic law, fertility preservation has to be proposed in every situation of infertility risk. To date, there is no cohort study dedicated to fertility preservation by oocyte freezing in this specific subgroup of patients. The purpose of the study is to prospectively evaluate the oocyte number and quality after controlled ovarian hyperstimulation in patients with recurrent ovarian cysts.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • women with benign ovarian tumor with high risk of recurrence, i-e, endometrioma,dermoid cysts or mucinous cysts.
  • women with previous surgery and/or high risk of ovarian damage: bilateral cysts, cystdiameter higher than 5 cms
  • Having a social insurance
  • Able to give an informed consent

Exclusion

Exclusion Criteria:

  • Borderline tumors
  • Undetectable AMH levels
  • Personal history of thrombo-embolic events
  • pregnancy

Study Design

Total Participants: 100
Study Start date:
July 28, 2021
Estimated Completion Date:
December 31, 2022

Connect with a study center

  • Hop Jeanne de Flandre Chu Lille

    Lille, 59037
    France

    Active - Recruiting

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