Intra-arterial Infusion Chemotherapy Combined With Sodium Bicarbonate for Unresectable Gastric Cancer

Inclusion Criteria:

1. Patients aged 18 to 75 years;

2. Ultrasound gastroscopy or imaging (CT) can diagnose potentially unresectable gastriccancer (T4a-bN2-3M0) with indications of neoadjuvant chemotherapy or transformationtherapy;

3. Pathological diagnosis of gastric cancer;

4. No contraindication of chemotherapy;

5. Patients who did not undergo chemotherapy or were diagnosed for the first time.

Exclusion Criteria:

1. Those who fail to comply with the requirements of the trial, obviously violate thisregimen, or change to other regimens in the course of treatment;

2. The life expectancy of patients with extensive systemic metastasis is less than 3months;

3. Leukocyte count is less than 2109/L and platelet count is less than 7510^9/L;

4. Severe heart, liver and kidney diseases, unable to tolerate chemotherapy;

5. Patients without gastric cancer complications such as massive gastrointestinalbleeding and perforation need to be treated in emergency department;

6. Patients with distant metastasis (excluding group 16 lymph node metastasis);

7. Patients with other tumors, with a history of malignant tumors (excluding earlyprimary cancers);

8. The patient himself asked to withdraw from the trial;

9. Researchers believe that patients are not suitable for this study.