Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients

Last updated: January 14, 2019
Sponsor: Schön Klinik Berchtesgadener Land
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT03802357
AAT Training
  • Ages 40-80
  • All Genders

Study Summary

Pulmonary rehabilitation (PR) including exercise training is highly effective by improving health-related quality of life, exercise capacity and symptoms in patients with chronic obstructive pulmonary disease (COPD). Therefore, PR is a main component in the management of COPD. In a former study patients with Alpha-1 Antitrypsin deficiency (A1ATD)-related COPD (genotype PiZZ) have been found to show smaller improvements in exercise capacity after a 3-week inpatient PR program compared to COPD patients without A1ATD (genotype PiMM)[1]. These between-group differences were mirrored by missing adaptations of the fatigue-resistant skeletal muscle fibre type I in A1ATD patients. This was in contrast to COPD patients without A1ATD who increased the proportion of this fibre type after PR. Myofibre type I is crucial because it enables patients for physical endurance activities (walking, cycling etc.) during their daily life.

The aim of this study is to compare the effects of an exercise Training program with high vs. moderate Training intensity in order to find a Training modality which improves Training effects in A1ATD patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • COPD patients with A1ATD (genotype PiZZ)

  • COPD patients without A1ATD (genotype PiMM)

  • Global initiative for chronic obstructive lung disease (GOLD) stage III-IV

  • Medical Treatment according to recent A1ATD guidelines

Exclusion

Exclusion Criteria:

  • General exclusion criteria for physical Training such as acute coronary Syndrome,acute myo- or pericarditis, acute lung embolism, acute heart failure, orthopediccomorbidities which prevent patients from participating in exercise Training program.

  • No written informed consent

  • Non-compliance

Study Design

Total Participants: 30
Study Start date:
January 10, 2019
Estimated Completion Date:
December 31, 2021

Connect with a study center

  • Schoen Klinik Berchtesgadener Land

    Schönau Am Königssee, 83471
    Germany

    Active - Recruiting

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