Phase
Condition
Inflammation
Heart Failure
Chest Pain
Treatment
Anakinra
Placebo
Clinical Study ID
Ages > 21 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
All 6 criteria need to be met for enrollment of the patient in the study
- Primary diagnosis for hospitalization is decompensated heart failure established asthe finding at admission of both conditions listed below:
dyspnea or respiratory distress or tachypnea at rest or with minimal exertion;
evidence of elevated cardiac filling pressure or pulmonary congestion (at leastone of the conditions must be met):
pulmonary congestion/edema at physical exam OR chest XRay;
plasma BNP levels ≥200 pg/mL;
invasive measurement of left ventricular end-diastolic pressure >18 mmHg or ofpulmonary artery occluding pressure (wedge) >16 mmHg.
The patient has a prior documentation of impaired left ventricular systolic function (ejection fraction ≤40%) at most recent assessment by any imaging modality (within 12 months).
The patient is now clinically stable, euvolemic, and meets standard criteria forhospital discharge as documented by all the 3 conditions listed below:
absence of dyspnea or pulmonary congestion/distress at rest;
absence of pitting edema in the lower extremities, or in any other region;
stable hemodynamic parameters (blood pressure, heart rate).
The patient is of age ≥21 years old, and is willing and able to provide writteninformed consent.
The patient is willing and able to comply with the protocol (i.e.,self-administration, or exercise test).
The patient has screening high sensitivity plasma C-reactive protein levels (hsCRP) >2 mg/L.
Exclusion
Exclusion Criteria:
Subjects will not be eligible if they meet any of the following 15 exclusion criteria.
The primary diagnosis for admission is NOT decompensated heart failure, includingdiagnosis of acute coronary syndromes, hypertensive urgency/emergency, tachy- orbrady-arrhythmias.
Concomitant clinically significant comorbidities that would interfere with theexecution or interpretation of the study including but not limited to acute coronarysyndromes, uncontrolled hypertension or orthostatic hypotension, tachy- orbrady-arrhythmias, acute or chronic pulmonary disease or neuromuscular disordersaffecting respiration.
Recent (previous 3 months) or planned resynchronization therapy (CRT), or valvesurgeries.
Previous or planned implantation of left ventricular assist devices or hearttransplant.
Chronic use of intravenous inotropes.
Recent (<14 days) use of immunosuppressive or anti-inflammatory drugs (includingoral corticosteroids at a dose of prednisone equivalent of 0.5 mg/kg/day but notincluding inhaled or low dose oral corticosteroids or non-steroidalanti-inflammatory drugs).
Chronic inflammatory disorder (including but not limited to rheumatoid arthritis,systemic lupus erythematosus).
Active infection (of any type), including chronic/recurrent infectious disease (i.e.HBV, HCV, and HIV/AIDS) - but excluding HCV+ with undetectable plasma RNA.
Active malignancy - excluding carcinoma in situ [any location] or localizednon-melanoma skin cancer.
Any comorbidity limiting survival or ability to complete the study.
Stage V kidney disease or on renal-replacement therapy.
Neutropenia (<1,500/mm3 or <1,000/mm3 in African-American patients).
Pregnancy.
Angina, hypertension, arrhythmias, electrocardiograph (ECG) changes, or othernon-cardiac limitations (i.e., peak respiratory exchange ratio VCO2/VO2 [RER]<1.0,reflecting sub-maximal test) that limit maximum exertion during CPX obtained duringthe baseline testing.
Hypersensitivity to Kineret or to E. coli derived products. 16) Evidence of COVID19within the last 60 days or recent (21 days) exposure to close personal contact.
Study Design
Study Description
Connect with a study center
Virginia Commonwealth University
Richmond, Virginia 23298
United StatesSite Not Available
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