CHILDNEPH The Canadian Childhood Nephrotic Syndrome Study

Last updated: May 2, 2019
Sponsor: University of Calgary
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Disease

Nephropathy

Kidney Failure (Pediatric)

Treatment

N/A

Clinical Study ID

NCT03786263
REB13-0059
  • Ages 1-17
  • All Genders

Study Summary

CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. The disease mechanism is not yet understood, and long-term use of steroids can affect children's health. This study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis with Nephrotic Sydrome at initial presentation, first or second relapse

Exclusion

Exclusion Criteria:

  • unable to participate in English or French

  • Nephrotic Syndrome is secondary to other disease

  • Younger than one year old or older than 17 years

Study Design

Total Participants: 400
Study Start date:
August 03, 2014
Estimated Completion Date:
March 31, 2022

Study Description

CHILDNEPH is an ongoing prospective longitudinal study of children with incident and prevalent nephrotic syndrome. Children are recruited from 12 centres across Canada and followed for at least 30 months. The project starting in August of 2013 with the goal of following 400 patients. Data is collected at enrollment, beginning and end of each relapse, semi-annual visits and end of study. Detailed prescription data is collected regarding glucocorticoids and all second line agents. All relapses are recorded with time to urinary remission of proteinuria.

The investigators are moving towards registry based trials to determine optimal treatment protocols for nephrotic syndrome with an overall goal to minimize glucocorticoid exposure, a patient priority.

Connect with a study center

  • Alberta Children's Hospital

    Calgary, Alberta T3B 6A8
    Canada

    Active - Recruiting

  • Stollery Children's Hospital, University of Alberta

    Edmonton, Alberta T6G 2B7
    Canada

    Active - Recruiting

  • British Columbia Children's Hospital

    Vancouver, British Columbia V6H 3V4
    Canada

    Active - Recruiting

  • Winnipeg Children's Hospital, University of Manitoba

    Winnipeg, Manitoba R3A 1S1
    Canada

    Active - Recruiting

  • IWK Health Centre

    Halifax, Nova Scotia B3H 1V7
    Canada

    Active - Recruiting

  • McMaster Children's Hospital

    Hamilton, Ontario L8N 3Z5
    Canada

    Active - Recruiting

  • Children's Hospital, London Health Sciences Centre

    London, Ontario N6A 5W9
    Canada

    Active - Recruiting

  • Children's Hospital of Eastern Ontario (CHEO) University of Ottawa

    Ottawa, Ontario K1H 8L1
    Canada

    Active - Recruiting

  • The Hospital for Sick Children (SickKids)

    Toronto, Ontario M5G 1X8
    Canada

    Active - Recruiting

  • CHU Ste. Justine

    Montréal, Quebec B3H 1V7
    Canada

    Active - Recruiting

  • Montreal Children's Hospital - McGill University

    Montréal, Quebec H4A 3J1
    Canada

    Active - Recruiting

  • Royal University Hospital, University of Saskatchewan

    Saskatoon, Saskatchewan S7N 0W8
    Canada

    Active - Recruiting

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