Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Phase

1/2

Condition

Neoplasms

Neoplasm Metastasis

Metastatic Cancer

Treatment

Afatinib

MRTX849

Pembrolizumab

Clinical Study ID

NCT03785249

CA239-0008

849-001

CA239-0008

Ages > 18
All Genders

Study Summary

This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Histologically confirmed diagnosis of a solid tumor malignancy with KRAS G12Cmutation
Unresectable or metastatic disease
Standard treatment is not available or patient declines; first-line treatment forNSCLC for certain cohorts
Adequate organ function

Exclusion

Exclusion Criteria:

History of intestinal disease or major gastric surgery or inability to swallow oralmedications
Other active cancer

Study Design

Afatinib

1/2

January 15, 2019

January 16, 2026

Study Description

This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.

Connect with a study center

PanOncology Trials
San Juan, 00935
Puerto Rico
Active - Recruiting
PanOncology Trials - Rio Piedras Medical Center
San Juan, 00935
Puerto Rico
Active - Recruiting
ONeal Comprehensive Cancer Center at the University of Alabama at Birmingham
Birmingham, Alabama 35294
United States
Active - Recruiting
University of Alabama at Birmingham
Birmingham, Alabama 35294
United States
Completed
Alaska Oncology and Hematology
Anchorage, Alaska 99508
United States
Active - Recruiting
Mayo Clinic Arizona - Phoenix Campus
Phoenix, Arizona 85054
United States
Active - Recruiting
Mayo Clinic in Arizona
Phoenix, Arizona 85054
United States
Active - Recruiting
Local Institution - 001-807
Scottsdale, Arizona 85258
United States
Site Not Available
Arizona Oncology Associates
Tucson, Arizona 85704
United States
Active - Recruiting
Local Institution - 001-873-A
Tucson, Arizona 85704
United States
Site Not Available
USOR - Arizona Oncology - Tucson - Rudasill
Tucson, Arizona 85704
United States
Active - Recruiting
Kaiser Permanente-Bellflower Medical Offices
Bellflower, California 90706
United States
Site Not Available
Local Institution - 001-840-B
Bellflower, California 90706
United States
Site Not Available
Beverly Hills Cancer Center
Beverly Hills, California 90211
United States
Active - Recruiting
City of Hope
Duarte, California 91010
United States
Active - Recruiting
City of Hope - Duarte (Main Campus)
Duarte, California 91010
United States
Active - Recruiting
Local Institution - 001-850-K
Dublin, California 94568
United States
Site Not Available
Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton
Fullerton, California 92835
United States
Active - Recruiting
St. Joseph Heritage Healthcare
Fullerton, California 92835
United States
Active - Recruiting
Local Institution - 001-840-C
Harbor City, California 90710
United States
Site Not Available
University of California San Diego Moores Cancer Center
La Jolla, California 92093
United States
Active - Recruiting
Cancer & Blood Specialty Clinic
Los Alamitos, California 90720
United States
Active - Recruiting
TRIO - Cancer and Blood Specialty Clinic
Los Alamitos, California 90720
United States
Active - Recruiting
Southern California Permanente Medical Group - Los Angeles Medical Center
Los Angeles, California 90027
United States
Active - Recruiting
Valkyrie Clinical Trials
Los Angeles, California 90067
United States
Active - Recruiting
Hoag Memorial Hospital Presbyterian
Newport Beach, California 92663
United States
Active - Recruiting
Hoag Memorial Hospital Presbyterian - Newport Beach
Newport Beach, California 92663
United States
Active - Recruiting
Local Institution - 001-850-B
Oakland, California 94611
United States
Site Not Available
University of California Irvine Medical Center
Orange, California 92868
United States
Active - Recruiting
University of California, Irvine
Orange, California 92868
United States
Active - Recruiting
Local Institution - 001-850-C
Roseville, California 95661
United States
Site Not Available
Local Institution - 001-850-D
Sacramento, California 95825
United States
Site Not Available
Local Institution - 001-850-J
Sacramento, California 95814
United States
Site Not Available
California Cancer Associates for Research and Excellence
San Diego, California 92111
United States
Active - Recruiting
California Cancer Associates for Research and Excellence (cCARE) - San Diego 4S Ranch
San Diego, California 92111
United States
Active - Recruiting
Local Institution - 001-840-A
San Diego, California 92120
United States
Site Not Available
Local Institution - 001-850-E
San Francisco, California 94115
United States
Site Not Available
Local Institution - 001-850-H
San Francisco, California 94080
United States
Site Not Available
Local Institution - 001-850-F
San Jose, California 95119
United States
Site Not Available
Local Institution - 001-850-A
San Leandro, California 94577
United States
Site Not Available
Ridley - Tree Cancer Center - Santa Barbara
Santa Barbara, California 93105
United States
Active - Recruiting
Local Institution - 001-850-I
Santa Clara, California 95051
United States
Site Not Available
Local Institution - 001-884-A
Solvang, California 93463
United States
Site Not Available
Kaiser Permanente
Vallejo, California 94589
United States
Active - Recruiting
Kaiser Permanente - Vallejo Medical Center
Vallejo, California 94589
United States
Active - Recruiting
Local Institution - 001-850-G
Walnut Creek, California 94596
United States
Site Not Available
Local Institution - 001-872
Aurora, Colorado 80012
United States
Site Not Available
Rocky Mountain Cancer Centers
Aurora, Colorado 80012
United States
Active - Recruiting
UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center
Aurora, Colorado 80045
United States
Active - Recruiting
USOR - Rocky Mountain Cancer Centers - Aurora
Aurora, Colorado 80012
United States
Active - Recruiting
University of Colorado Hospital
Aurora, Colorado 80045
United States
Active - Recruiting
Local Institution - 001-872-H
Boulder, Colorado 80303
United States
Site Not Available
Local Institution - 001-872-E
Colorado Springs, Colorado 80907
United States
Site Not Available
Local Institution - 001-872-B
Denver, Colorado 80218
United States
Site Not Available
Local Institution - 001-951 - A
Denver, Colorado 80218
United States
Site Not Available
Local Institution - 001-951 - B
Denver, Colorado 80218
United States
Site Not Available
SCL Health - Saint Joseph Hospital Cancer Center
Denver, Colorado 80218
United States
Site Not Available
Cancer Centers of Colorado - St. Marys Regional Hospital
Grand Junction, Colorado 81501
United States
Active - Recruiting
St. Mary's Hospital & Regional Medical Center - Research
Grand Junction, Colorado 81501
United States
Site Not Available
SCL Health - Saint Joseph Hospital Cancer Center
Lafayette, Colorado 80026
United States
Active - Recruiting
Local Institution - 001-872-A
Lakewood, Colorado 80228
United States
Site Not Available
Local Institution - 001-872-D
Littleton, Colorado 80218
United States
Site Not Available
Local Institution - 001-872-K
Lone Tree, Colorado 80124
United States
Site Not Available
Local Institution - 001-872-C
Longmont, Colorado 80501
United States
Site Not Available
Local Institution - 001-872-J
Parker, Colorado 80138
United States
Site Not Available
Local Institution - 001-872-F
Pueblo, Colorado 81008
United States
Site Not Available
Local Institution - 001-872-G
Pueblo, Colorado 81008
United States
Site Not Available
Local Institution - 001-872-I
Thornton, Colorado 80260
United States
Site Not Available
Yale Cancer Center
New Haven, Connecticut 06510
United States
Active - Recruiting
Medical Oncology Hematology Consultants
Newark, Delaware 19713
United States
Active - Recruiting
USOR - Medical Oncology Hematology Consultants
Newark, Delaware 19713-2055
United States
Active - Recruiting
Local Institution - 001-929i
Altamonte Springs, Florida 32701
United States
Site Not Available
Boca Raton Clinical Research Associates, Inc.
Boca Raton, Florida 33432
United States
Active - Recruiting
Local Institution - 001-929c
Brandon, Florida 33511
United States
Site Not Available
Local Institution - 001-929g
Clearwater, Florida 33761
United States
Site Not Available
Local Institution - 001-926b
Daytona Beach, Florida 32117
United States
Site Not Available
SCRI - Florida Cancer Specialists - South Region Research Office
Fort Myers, Florida 33901
United States
Active - Recruiting
SCRI - Florida Cancer Specialists- South
Fort Myers, Florida 33901
United States
Active - Recruiting
Local Institution - 001-929b
Gainesville, Florida 32605
United States
Site Not Available
Mayo Clinic - Jacksonville
Jacksonville, Florida 32224
United States
Active - Recruiting
Mayo Clinic in Florida
Jacksonville, Florida 32224
United States
Active - Recruiting
Local Institution - 001-929m
Lady Lake, Florida 32159
United States
Site Not Available
Local Institution - 001-929e
Largo, Florida 33770
United States
Site Not Available
Local Institution - 001-929n
Lecanto, Florida 34461
United States
Site Not Available
Miami Cancer Institute
Miami, Florida 33176
United States
Active - Recruiting
Miami Cancer Institute Baptist Health
Miami, Florida 33176
United States
Active - Recruiting
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida 33140
United States
Active - Recruiting
Florida Cancer Affiliates - Ocala
Ocala, Florida 34471
United States
Active - Recruiting
Florida Cancer Affiliates - Ocala - Main
Ocala, Florida 34474
United States
Active - Recruiting
Local Institution - 001-929p
Ocala, Florida 34474
United States
Site Not Available
Local Institution - 001-929j
Orange City, Florida 32763
United States
Site Not Available
Mid Florida Cancer Centers - Orange City
Orange City, Florida 32763
United States
Active - Recruiting
Mid Florida Hematology and Oncology Center
Orange City, Florida 37263
United States
Active - Recruiting
Local Institution - 001-929l
Orlando, Florida 32806
United States
Site Not Available
Woodlands Medical Specialists
Pensacola, Florida 32503
United States
Active - Recruiting
BRCR Medical Center
Plantation, Florida 33322
United States
Site Not Available
Local Institution - 001-929a
Saint Petersburg, Florida 33705
United States
Site Not Available
SCRI - Florida Cancer Specialists - North Region Research Office
Saint Petersburg, Florida 33705
United States
Active - Recruiting
SCRI - Florida Cancer Specialists-North
Saint Petersburg, Florida 33705
United States
Active - Recruiting
Local Institution - 001-929h
Spring Hill, Florida 34608
United States
Site Not Available
Local Institution - 001-926d
Stuart, Florida 34994
United States
Site Not Available
Local Institution - 001-929d
Tampa, Florida 33607
United States
Site Not Available
Local Institution - 001-929k
Tavares, Florida 32778
United States
Site Not Available
Local Institution - 001-929f
Trinity, Florida 34655
United States
Site Not Available
Local Institution - 001-926c
Vero Beach, Florida 32960
United States
Site Not Available
Local Institution - 001-926a
Wellington, Florida 33414
United States
Site Not Available
SCRI - Florida Cancer Specialists - East Region Research Office
West Palm Beach, Florida 33401
United States
Active - Recruiting
SCRI - Florida Cancer Specialists- East
West Palm Beach, Florida 33401
United States
Active - Recruiting
Local Institution - 001-929o
Winter Park, Florida 32789
United States
Site Not Available
University Cancer & Blood Center (UCBC) - Athens
Athens, Georgia 30607
United States
Active - Recruiting
University Cancer and Blood Center
Athens, Georgia 30607
United States
Active - Recruiting
Local Institution - 001-835-C
Austell, Georgia 30106
United States
Site Not Available
Local Institution - 001-835-E
Austell, Georgia 30106
United States
Site Not Available
Local Institution - 001-835-D
Carrollton, Georgia 30117
United States
Site Not Available
Local Institution - 001-835-F
Carrollton, Georgia 30117
United States
Site Not Available
Local Institution - 001-835-A
Cartersville, Georgia 30121
United States
Site Not Available
Local Institution - 001-835-B
Douglasville, Georgia 30134
United States
Site Not Available
Northwest Georgia Oncology Centers Wellstar - Marietta
Marietta, Georgia 30060
United States
Active - Recruiting
Northwest Georgia Oncology Centers, PC
Marietta, Georgia 30060
United States
Active - Recruiting
Local Institution - 001-828
Chicago, Illinois 60611
United States
Site Not Available
Affiliated Oncologists - Millenium Medical Center
Chicago Ridge, Illinois 60415
United States
Active - Recruiting
Affiliated Oncologists - Millenium Medical Center - Chicago Ridge
Chicago Ridge, Illinois 60415
United States
Active - Recruiting
Illinois Cancer Specialists - Niles
Niles, Illinois 60714
United States
Active - Recruiting
USOR - Illinois Cancer Specialists - Niles
Niles, Illinois 60714
United States
Active - Recruiting
Memorial Hospital
South Bend, Indiana 46601
United States
Active - Recruiting
Memorial Hospital South Bend
South Bend, Indiana 46601
United States
Active - Recruiting
Local Institution - 001-831
Iowa City, Iowa 52242
United States
Site Not Available
University of Iowa
Iowa City, Iowa 52242
United States
Active - Recruiting
University of Iowa Hospital & Clinics
Iowa City, Iowa 52242
United States
Active - Recruiting
University of Kansas Medical Center
Westwood, Kansas 66205
United States
Active - Recruiting
University of Kentucky
Lexington, Kentucky 40536
United States
Active - Recruiting
SCRI - Hematology Oncology Clinic
Baton Rouge, Louisiana 70809
United States
Active - Recruiting
SCRI - Hematology Oncology Clinic - Baton Rouge
Baton Rouge, Louisiana 70809
United States
Active - Recruiting
Main Health Cancer Center Biddeford
Biddeford, Maine 04005
United States
Active - Recruiting
MaineHealth Cancer Care - Biddeford
Biddeford, Maine 04005
United States
Active - Recruiting
Local Institution - 001-881-B
Brandywine, Maryland 20613
United States
Site Not Available
Maryland Oncology Hematology - Columbia
Columbia, Maryland 21044
United States
Active - Recruiting
Maryland Oncology Hematology-Columbia
Columbia, Maryland 21044
United States
Active - Recruiting
Local Institution - 001-881-A
Silver Spring, Maryland 20904
United States
Site Not Available
Dana Farber Cancer Institute
Boston, Massachusetts 02215
United States
Active - Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
Active - Recruiting
Massachusetts General Hospital
Boston, Massachusetts 02114
United States
Active - Recruiting
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan 48201
United States
Active - Recruiting
Henry Ford Health System
Detroit, Michigan 48202
United States
Active - Recruiting
Henry Ford Medical Center
Detroit, Michigan 48377
United States
Active - Recruiting
Local Institution - 001-842-A
Farmington Hills, Michigan 48334
United States
Site Not Available
Local Institution - 001-838-F
Coon Rapids, Minnesota 55433
United States
Site Not Available
Local Institution - 001-838-E
Edina, Minnesota 55435
United States
Site Not Available
Local Institution - 001-875 - D
Edina, Minnesota 55435
United States
Site Not Available
Local Institution - 001-838-D
Maplewood, Minnesota 55109
United States
Site Not Available
Local Institution - 001-875 - A
Maplewood, Minnesota 55109
United States
Site Not Available
Local Institution - 001-822-A
Minneapolis, Minnesota 55455
United States
Site Not Available
Local Institution - 001-838-C
Minneapolis, Minnesota 55404
United States
Site Not Available
Local Institution - 001-838-G
Minneapolis, Minnesota 55415
United States
Site Not Available
Masonic Cancer Center
Minneapolis, Minnesota 55455
United States
Active - Recruiting
Minnesota Oncology
Minneapolis, Minnesota 55102
United States
Active - Recruiting
USOR - Minnesota Oncology - Minneapolis Clinic
Minneapolis, Minnesota 55404
United States
Active - Recruiting
University of Minnesota
Minneapolis, Minnesota 55454
United States
Active - Recruiting
Mayo Clinic - Rochester
Rochester, Minnesota 55905
United States
Active - Recruiting
Mayo Clinic in Minnesota
Rochester, Minnesota 55905
United States
Active - Recruiting
Local Institution - 001-838-B
Saint Louis Park, Minnesota 55426-5000
United States
Site Not Available
Metro-Minnesota Community Oncology Research Consortium
Saint Louis Park, Minnesota 55416
United States
Active - Recruiting
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Louis Park, Minnesota 55416
United States
Active - Recruiting
Local Institution - 001-838-A
Saint Paul, Minnesota 55101
United States
Site Not Available
Local Institution - 001-875 - B
Saint Paul, Minnesota 55102
United States
Site Not Available
Local Institution - 001-875 - C
Woodbury, Minnesota 55125
United States
Site Not Available
Central Care Cancer Center - Bolivar
Bolivar, Missouri 65613
United States
Active - Recruiting
Goldschmidt Cancer Center
Jefferson City, Missouri 65109
United States
Active - Recruiting
Goldschmidt Cancer Center- Central Region Medical Center
Jefferson City, Missouri 65109
United States
Active - Recruiting
Frontier Cancer Center
Billings, Montana 59102
United States
Active - Recruiting
Sisters of Charity of Leavenworth Health St. Marys
Billings, Montana 59102
United States
Active - Recruiting
Local Institution - 001-544A
Omaha, Nebraska 68118
United States
Site Not Available
Local Institution - 001-544B
Omaha, Nebraska 68105-1850
United States
Site Not Available
Methodist Estabrook Cancer Center
Omaha, Nebraska 68114
United States
Active - Recruiting
Nebraska Cancer Specialists
Omaha, Nebraska 68130
United States
Active - Recruiting
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
Active - Recruiting
Local Institution - 001-860A
Henderson, Nevada 89052
United States
Site Not Available
Local Institution - 001-860B
Henderson, Nevada 89074
United States
Site Not Available
Local Institution - 001-860C
Henderson, Nevada 89052
United States
Site Not Available
USOR - Comprehensive Cancer Centers of Nevada - Southeast Henderson
Henderson, Nevada 89074
United States
Active - Recruiting
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89169
United States
Site Not Available
Local Institution - 001-860D
Las Vegas, Nevada 89144
United States
Site Not Available
Local Institution - 001-860E
Las Vegas, Nevada 89128
United States
Site Not Available
Local Institution - 001-860F
Las Vegas, Nevada 89148
United States
Site Not Available
New York Oncology Hematology - Albany Medical Center
Albany, New York 12206
United States
Active - Recruiting
Roswell Park
Buffalo, New York 14263
United States
Active - Recruiting
Roswell Park Comprehensive Cancer Center
Buffalo, New York 14203
United States
Active - Recruiting
Local Institution - 001-832
Lake Success, New York 11042
United States
Site Not Available
Local Institution - 001-583
New York, New York 10032
United States
Site Not Available
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United States
Active - Recruiting
Memorial Sloan Kettering Cancer Center - New York
New York, New York 10065
United States
Active - Recruiting
Perlmutter Cancer Center
New York, New York 10016
United States
Active - Recruiting
Perlmutter Cancer Center - 34th Street
New York, New York 10016
United States
Active - Recruiting
University of North Carolina
Chapel Hill, North Carolina 27514
United States
Active - Recruiting
University of North Carolina Hospitals
Chapel Hill, North Carolina 27514
United States
Active - Recruiting
FirstHealth Outpatient Cancer Center
Pinehurst, North Carolina 28374
United States
Active - Recruiting
The Christ Hospital
Cincinnati, Ohio 45219
United States
Active - Recruiting
The Christ Hospital Cancer Center
Cincinnati, Ohio 45219
United States
Active - Recruiting
University of Cincinnati Health Barrett Cancer Center
Cincinnati, Ohio 45267
United States
Active - Recruiting
Cleveland Clinic
Cleveland, Ohio 44195
United States
Active - Recruiting
Cleveland Clinic Lerner College of Medicine
Cleveland, Ohio 44195
United States
Active - Recruiting
Local Institution - 001-833 - A
Columbus, Ohio 43210
United States
Site Not Available
Local Institution - 001-833 - B
Columbus, Ohio 43221
United States
Site Not Available
Local Institution - 001-833 - C
Columbus, Ohio 43203
United States
Site Not Available
Local Institution - 001-833 - D
Columbus, Ohio 43212
United States
Site Not Available
Local Institution - 001-833 - F
Columbus, Ohio 43210
United States
Site Not Available
Local Institution - 001-833 - G
Columbus, Ohio 43221
United States
Site Not Available
Local Institution - 001-833 - H
Columbus, Ohio 43201
United States
Site Not Available
Local Institution - 001-833 - I
Columbus, Ohio 43212
United States
Site Not Available
Local Institution - 001-833 - J
Columbus, Ohio 43203
United States
Site Not Available
OSU Medical Center
Columbus, Ohio 43210
United States
Active - Recruiting
SCRI - Mark H. Zangmeister Cancer Center
Columbus, Ohio 43219
United States
Active - Recruiting
The Ohio State University College of Medicine
Columbus, Ohio 43210
United States
Active - Recruiting
Local Institution - 001-833 - E
Gahanna, Ohio 43230
United States
Site Not Available
Kettering Cancer Center
Kettering, Ohio 45429
United States
Site Not Available
Kettering Health Cancer Center - Main Campus
Kettering, Ohio 45429
United States
Active - Recruiting
Local Institution - 001-836-A
Kettering, Ohio 45429
United States
Site Not Available
Cancer Centers of Southwest Oklahoma - Leah M. Fitch Cancer Center
Lawton, Oklahoma 73505
United States
Active - Recruiting
Local Institution - 001-580
Oklahoma City, Oklahoma 73142
United States
Site Not Available
Local Institution - 001-584
Tulsa, Oklahoma 74146
United States
Completed
Oklahoma Cancer Specialist & Research Institute
Tulsa, Oklahoma 74146
United States
Active - Recruiting
Oklahoma Cancer Specialists and Research Institute (OCSRI) - Tulsa
Tulsa, Oklahoma 74146
United States
Site Not Available
Local Institution - 001-586-A
Bend, Oregon 97701
United States
Site Not Available
St. Charles Health System
Bend, Oregon 97701
United States
Active - Recruiting
Willamette Valley Cancer Institute and Research Center - Eugene
Eugene, Oregon 97401
United States
Active - Recruiting
Lehigh Valley Heath
Allentown, Pennsylvania 18103
United States
Active - Recruiting
Lehigh Valley Physician Group Hematology Oncology
Allentown, Pennsylvania 18103
United States
Active - Recruiting
Local Institution - 001-837-A
Bethlehem, Pennsylvania 18017
United States
Site Not Available
Penn State Cancer Institute
Hershey, Pennsylvania 17033-0850
United States
Active - Recruiting
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania 17033
United States
Active - Recruiting
Alliance Cancer Specialists
Media, Pennsylvania 19063
United States
Active - Recruiting
USOR - Alliance Cancer Specialists - Media (Cancer Center at Riddle Memorial Hospital)
Media, Pennsylvania 19063
United States
Active - Recruiting
Charleston Oncology P.A.
Charleston, South Carolina 29414
United States
Completed
Medical University of South Carolina
Charleston, South Carolina 29425
United States
Active - Recruiting
USOR - Charleston Hematology Oncology Associates
Charleston, South Carolina 29414
United States
Active - Recruiting
Local Institution - 001-801-G
Gallatin, Tennessee 37066
United States
Site Not Available
Local Institution - 001-801-A
Hendersonville, Tennessee 37075
United States
Site Not Available
Local Institution - 001-801-D
Hermitage, Tennessee 37076
United States
Site Not Available
Local Institution - 001-801-F
Murfreesboro, Tennessee 37129
United States
Site Not Available
Local Institution - 001-801-B
Nashville, Tennessee 37203
United States
Site Not Available
Local Institution - 001-801-C
Nashville, Tennessee 37211
United States
Site Not Available
Local Institution - 001-801-E
Nashville, Tennessee 37207
United States
Site Not Available
Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology
Nashville, Tennessee 37203
United States
Active - Recruiting
Tennessee Oncology/The Sarah Cannon Research Institute
Nashville, Tennessee 37203
United States
Active - Recruiting
Local Institution - 001-888-B
Arlington, Texas 76012
United States
Site Not Available
Texas Oncology-Arlington
Arlington, Texas 76014
United States
Site Not Available
USOR - Texas Oncology Dallas Fort Worth West (DFWW) - Arlington South
Arlington, Texas 76012
United States
Active - Recruiting
USOR - Texas Oncology - Austin Central
Austin, Texas 78731
United States
Active - Recruiting
Local Institution - 001-848a
Conroe, Texas 77384
United States
Site Not Available
Mary Crowley Cancer Research
Dallas, Texas 75231
United States
Active - Recruiting
Mary Crowley Cancer Research - Medical City Hospital
Dallas, Texas 75230
United States
Active - Recruiting
Texas Oncology at Presbyterian Dallas
Dallas, Texas 75231
United States
Active - Recruiting
Texas Oncology- DFW
Dallas, Texas 75246
United States
Active - Recruiting
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
United States
Active - Recruiting
USOR - Texas Oncology - Dallas Fort Worth (DFW) - Presbyterian Cancer Center Dallas
Dallas, Texas 75231
United States
Active - Recruiting
USOR Texas Oncology Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
United States
Active - Recruiting
USOR - Texas Oncology Northeast Texas - Denison
Denison, Texas 75020
United States
Active - Recruiting
Texas Oncology
Fort Worth, Texas 76104
United States
Site Not Available
Texas Oncology - Dallas Fort Worth (DFW) - Fort Worth
Fort Worth, Texas 76104
United States
Active - Recruiting
Local Institution - 001-935A
Houston, Texas 77090
United States
Site Not Available
Oncology Consultants - Texas Medical Center
Houston, Texas 77030
United States
Active - Recruiting
The University of Texas MD Anderson Cancer Center
Houston, Texas 77030
United States
Active - Recruiting
University of Texas MD Anderson Cancer Center
Houston, Texas 77030
United States
Active - Recruiting
Local Institution - 001-999
Irving, Texas 75063
United States
Site Not Available
Local Institution - 001-935D
Kingwood, Texas 77339
United States
Site Not Available
Lumi Research
Kingwood, Texas 77339
United States
Active - Recruiting
Texas Oncology Midland
Midland, Texas 79701
United States
Active - Recruiting
USOR - Texas Oncology - Midland Allison Cancer Center
Midland, Texas 79701
United States
Active - Recruiting
START Center for Cancer Care
San Antonio, Texas 78229
United States
Active - Recruiting
South Texas Accelerated Research Therapeutics
San Antonio, Texas 78229
United States
Active - Recruiting
Local Institution - 001-935B
Shenandoah, Texas 77380
United States
Site Not Available
Local Institution - 001-935C
Spring, Texas 77389
United States
Site Not Available
Texas Oncology
Sugar Land, Texas 77479
United States
Active - Recruiting
Texas Oncology - Sugar Land
Sugar Land, Texas 77479
United States
Active - Recruiting
Local Institution - 001-935E
Tomball, Texas 77375
United States
Site Not Available
Texas Oncology
Tyler, Texas 75702
United States
Active - Recruiting
Texas Oncology - Northeast Texas Cancer and Research Institute - Tyler
Tyler, Texas 75702
United States
Active - Recruiting
Texas Oncology - Waco
Waco, Texas 76712
United States
Active - Recruiting
Texas Oncology Waco
Waco, Texas 76712
United States
Active - Recruiting
Local Institution - 001-919
Fairfax, Virginia 22031-4630
United States
Site Not Available
NEXT Virginia
Fairfax, Virginia 22031
United States
Active - Recruiting
Virginia Cancer Specialists
Fairfax, Virginia 22031
United States
Active - Recruiting
Hematology Oncology Associates of Fredericksburg
Fredericksburg, Virginia 24408
United States
Active - Recruiting
USOR - Virginia Oncology Associates - Newport News
Newport News, Virginia 23606
United States
Active - Recruiting
Virginia Oncology Associates-Newport News
Newport News, Virginia 23606
United States
Active - Recruiting
Local Institution - 001-882-A
Norfolk, Virginia 23502
United States
Site Not Available
Virginia Cancer Institute
Richmond, Virginia 23230
United States
Active - Recruiting
Virginia Cancer Institute - West End
Richmond, Virginia 23229
United States
Active - Recruiting
Fred Hutchinson Cancer Research Center
Seattle, Washington 98109
United States
Active - Recruiting
Seattle Cancer Care Alliance
Seattle, Washington 98109
United States
Active - Recruiting
USOR - Compass Oncology - Vancouver
Vancouver, Washington 98684
United States
Active - Recruiting
USOR - Northwest Cancer Specialists, P.C. dba Compass Oncology - Vancouver Cancer Center
Vancouver, Washington 98684
United States
Active - Recruiting
University Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United States
Active - Recruiting
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United States
Active - Recruiting

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Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Phase

Condition

Treatment

Clinical Study ID

Study Summary

Eligibility Criteria

Inclusion

Exclusion

Study Design

Study Description

Connect with a study center

PanOncology Trials

PanOncology Trials - Rio Piedras Medical Center

ONeal Comprehensive Cancer Center at the University of Alabama at Birmingham

University of Alabama at Birmingham

Alaska Oncology and Hematology

Mayo Clinic Arizona - Phoenix Campus

Mayo Clinic in Arizona

Local Institution - 001-807

Arizona Oncology Associates

Local Institution - 001-873-A

USOR - Arizona Oncology - Tucson - Rudasill

Kaiser Permanente-Bellflower Medical Offices

Local Institution - 001-840-B

Beverly Hills Cancer Center

City of Hope

City of Hope - Duarte (Main Campus)

Local Institution - 001-850-K

Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton

St. Joseph Heritage Healthcare

Local Institution - 001-840-C

University of California San Diego Moores Cancer Center

Cancer & Blood Specialty Clinic

TRIO - Cancer and Blood Specialty Clinic

Southern California Permanente Medical Group - Los Angeles Medical Center

Valkyrie Clinical Trials

Hoag Memorial Hospital Presbyterian

Hoag Memorial Hospital Presbyterian - Newport Beach

Local Institution - 001-850-B

University of California Irvine Medical Center

University of California, Irvine

Local Institution - 001-850-C

Local Institution - 001-850-D

Local Institution - 001-850-J

California Cancer Associates for Research and Excellence

California Cancer Associates for Research and Excellence (cCARE) - San Diego 4S Ranch

Local Institution - 001-840-A

Local Institution - 001-850-E

Local Institution - 001-850-H

Local Institution - 001-850-F

Local Institution - 001-850-A

Ridley - Tree Cancer Center - Santa Barbara

Local Institution - 001-850-I

Local Institution - 001-884-A

Kaiser Permanente

Kaiser Permanente - Vallejo Medical Center

Local Institution - 001-850-G

Local Institution - 001-872

Rocky Mountain Cancer Centers

UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center

USOR - Rocky Mountain Cancer Centers - Aurora

University of Colorado Hospital

Local Institution - 001-872-H

Local Institution - 001-872-E

Local Institution - 001-872-B

Local Institution - 001-951 - A

Local Institution - 001-951 - B

SCL Health - Saint Joseph Hospital Cancer Center

Cancer Centers of Colorado - St. Marys Regional Hospital

St. Mary's Hospital & Regional Medical Center - Research

SCL Health - Saint Joseph Hospital Cancer Center

Local Institution - 001-872-A

Local Institution - 001-872-D

Local Institution - 001-872-K

Local Institution - 001-872-C

Local Institution - 001-872-J

Local Institution - 001-872-F

Local Institution - 001-872-G

Local Institution - 001-872-I