Landiolol in Postoperative Atrial Fibrillation

Last updated: August 1, 2025
Sponsor: Hospices Civils de Lyon
Overall Status: Completed

Phase

3

Condition

Cardiac Disease

Arrhythmia

Chest Pain

Treatment

Landiolol

Placebo

Clinical Study ID

NCT03779178
69HCL16_0743
2018-000307-17
  • Ages > 18
  • All Genders

Study Summary

Postoperative atrial fibrillation is a common complication after cardiac surgery and is associated with an elevation of morbidity and mortality. The recommended treatment includes heart rate control with a beta blocker. Landiolol is a new-generation beta-blocker with favourable pharmacologic properties making an interesting drug to treat postoperative atrial fibrillation. However, Landiolol micro and macrocirculatory effects in the setting of atrial fibrillation are yet to describe. The aim of this study is to describe microcirculatory effects of incremental doses of landiolol in postoperative atrial fibrillation compared to a placebo. Our hypothesis is Landiolol will improve microcirculation disorders.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient underwent conventional cardiac surgery

  • Age > 18 years

  • Writing contentment

Exclusion

Exclusion Criteria:

  • Pre-existing chronic atrial fibrillation

  • Contraindication to beta-blockers

  • Circulatory shock (cardiac index<2.2 L/min and lactate>4mmol/L)

  • Distributive shock (cardiac index>2.2 L/min with norepinephrine dose > 0.3 µg/kg/minto reach mean arterial pressure > 65mmHg).

  • Acute respiratory distress

  • Major bleeding (>200mL/h)

  • Patient already included into an interventional clinical study

  • Pregnancy

  • No social security insurance

  • Patient not able to give consent (curators, patients deprived of public rights)

Study Design

Total Participants: 58
Treatment Group(s): 2
Primary Treatment: Landiolol
Phase: 3
Study Start date:
January 17, 2019
Estimated Completion Date:
December 04, 2019

Connect with a study center

  • Hôpital Louis Pradel

    Bron,
    France

    Site Not Available

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